Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 907-132-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted QSAR estimation method, according to ECHA Chapter R.7c guidance (2008). Substance is considered to be within the structural (aliphatic ether, aliphatic alcohol) and parametric (log Kow) domains of the model.
- Justification for type of information:
- Read across is based on the category approach. Please refer to attached category document.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Improved Method for Estimating Bioconcentration / Bioaccumulation Factor from Octanol/Water Partition Coefficient
- Author:
- Meylan WM, Howard PH, Boethling RS
- Year:
- 1 999
- Bibliographic source:
- Environ. Toxicol. Chem. 18(4): 664-672
Materials and methods
- Principles of method if other than guideline:
- The estmation is made using the U.S. EPA EPI Suite v4.10, and the embedded BCFBAF model v3.01. The estimation method and training set data are described in the cited reference of Meylan et al. 1999.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,6,9-trioxaundecane-1,11-diol
- EC Number:
- 203-989-9
- EC Name:
- 3,6,9-trioxaundecane-1,11-diol
- Cas Number:
- 112-60-7
- Molecular formula:
- C8H18O5
- IUPAC Name:
- 2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol
- Reference substance name:
- Tetraethylene glcyol
- IUPAC Name:
- Tetraethylene glcyol
- Details on test material:
- Test substance molecular structure entered to model as SMILES notation.
SMILES code: O(CCOCCOCCO)CCO
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable
Sampling and analysis
- Details on sampling:
- not applicable
Test solutions
- Vehicle:
- no
- Details on preparation of test solutions, spiked fish food or sediment:
- not applicable
Test organisms
- Details on test organisms:
- Generic fish BCF value is estimated, based on training set using a number of different fish species
Study design
- Test type:
- other: QSAR estimation based on structure and log Kow
Test conditions
- Hardness:
- not applicable
- Test temperature:
- not applicable
- pH:
- not applicable
- Dissolved oxygen:
- not applicable
- TOC:
- not applicable
- Salinity:
- not applicable
- Details on test conditions:
- not applicable
- Nominal and measured concentrations:
- not applicable
- Details on estimation of bioconcentration:
- Based on input SMILES code, and estimated log Kow value of -2.02, the model identified the occurrence of two aliphatic alcohol, two aliphatic ether, and eight methylene carbon (CH2) groups. A correction for molecular weight and an equation constant are also used in deriving BCF from the correlation with log Kow .
Results and discussion
Bioaccumulation factor
- Type:
- BCF
- Value:
- 3.2 L/kg
- Basis:
- whole body w.w.
- Details on kinetic parameters:
- not applicable
- Metabolites:
- not applicable
- Results with reference substance (positive control):
- not applicable
- Details on results:
- not applicable
- Reported statistics:
- not applicable
Any other information on results incl. tables
not applicable
Applicant's summary and conclusion
- Conclusions:
- The estimated BCF value is 3.2 L/kg w.w., based on correlation of log Kow and BCF values, with corrections for specific structural features and molecular weight. The substance is concluded to have very low potential for bioaccumulation in the aquatic environment.
- Executive summary:
not applicable
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.