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EC number: 904-551-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity LD50 in mice > 9500 mL/kg bw (8836 mg/kg bw)
Acute inhalation toxicity LC50 route to route extrapolation > 23000 mg/kg bw
Acute dermal toxicity LD50 in rabbits > 5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1955
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study was performed predating current guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 5 day observation period
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Carworth
- Housing: Individual cages
- Diet: Regular diet of Fox Blox
- Route of administration:
- oral: gavage
- Vehicle:
- other: Distilled water plus Tween 20 to aid in mixing
- Details on oral exposure:
- VEHICLE
- Actual amount of test material fed: 0.1, 0.14, 0.16, 0.18, 0.20, 0.30, and 0.40 mL corresponding with 5, 7, 8, 9, 10, 15, and 20 mL/kg, respectively.
- Justification for choice of vehicle: distilled water and Tween 20 to aid mixing.
DOSAGE PREPARATION
The test material was diluted one part plus four parts with diluted water plus Tween 20. - Doses:
- 5, 7, 8, 9, 10, 15, and 20 mL/kg
- No. of animals per sex per dose:
- 5, 5, 10, 10, 10,10, and 5 animals (sex unspecified) in the 5, 7, 8, 9, 10, 15, and 20 mL/kg dose goups, respectively.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 5 days
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 9 500 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 calculated with Behrens method
- Mortality:
- 0/5, 0/5, 1/10, 4/10, 7/10, 9/10, and 5/5 animals died within the 5 day observation period after exposure to 5, 7, 8, 9, 10, 15, and 20 mL/kg, respectively.
- Interpretation of results:
- other: Not classified
- Remarks:
- According to Regulation (EC) No. 1272/2008.
- Conclusions:
- The acute oral toxicity test showed an LD50 of 9500 mL/kg bw
- Executive summary:
A preguideline study was performed to identify the acute oral toxicity of the test substance in mice. In this study, 5, 5, 10, 10, 10,10, and 5 mice (sex unspecified) were administered with 5, 7, 8, 9, 10, 15, and 20 mL/kg . substance at dose levels of 5, 7, 8, 9, 10, 15, and 20 mL/kg bw. 0/5, 0/5, 1/10, 4/10, 7/10, 9/10, and 5/5 animals died within the 5 day observation period after exposure to 5, 7, 8, 9, 10, 15, and 20 mL/kg, respectively. Under the conditions of the test, the acute oral LD50 for the substance in mice was determined to be 9500 mL/kg bw (calculated with Behrens method).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study is carried out predating current guidelines
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 3 (intact skin)
3 (abraded skin) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed within the 14 day observation period.
- Other findings:
- Dry cracked skin was noted.
- Interpretation of results:
- other: Not classified
- Remarks:
- According to Regulation (EC) No. 1272/2008.
- Conclusions:
- The acute dermal toxicity test showed an LD50 > 5000 mg/kg bw
- Executive summary:
A preguideline study was performed to identify the acute dermal toxicity of the test substance.In this study 3 albino rabbits were administered with 5000 mg/kg neat test substance on the intact skin. The animals were exposed for 24 hours under occlusive conditions. No mortality was observed within the 14 -day observation period. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was > 5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Additional information
Oral
A preguideline study was performed to identify the acute oral toxicity of the test substance.In this study,5, 5, 10, 10, 10,10, and 5 mice (sex unspecified) were administered with 5, 7, 8, 9, 10, 15, and 20 mL/kg substance at dose levels of 5, 7, 8, 9, 10, 15, and 20 mL/kg bw. 0/5, 0/5, 1/10, 4/10, 7/10, 9/10, and 5/5 animals died within the 5 day observation period after exposure to 5, 7, 8, 9, 10, 15, and 20 mL/kg, respectively. Under the conditions of the test, the acute oral LD50 for the substance in mice was determined to be 9500 mL/kg bw (calculated with Behrens method). With a density of 0.9301 this equals to 8836 mg/kg bw.
Dermal
A preguideline study was performed to identify the acute dermal toxicity of the test substance.In this study 3 albino rabbits were administered with 5000 mg/kg neat test substance on the intact skin. The animals were exposed for 24 hours under occlusive conditions. No mortality was observed within the 14 -day observation period. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was > 5000 mg/kg bw.
Inhalation:
The acute inhalation toxicity for the substance can be derived using data on the acute oral toxicity using the following methodology*: CLP guidance (2015 3.1.6.1.8. Example 8, page 268): using the extrapolation formula 1 mg/kg bw = 0.0052 mg/L/4h. The LD50 of the substance for acute oral toxicity is 8836 mg/kg bw. This 8836 mg/kg bw can be converted to 45.9 mg/L = 45.9 gram/m3. Taking into account the inhalation absorption as 100% and oral absorption 50%, the acute inhalation toxicity would become 23.0 g/m3 = 23000 mg/m3. The maximum saturated vapour pressure for Hexalon is 685 mg/m3 (0.08 Pa (Vap Pr. Hexalon) x232(MW) / 8.3 (R, gas constant) x 297 (°K)). This means that Hexalon cannot reach a concentration higher than 685 mg/m3. The extrapolated inhalation LC50 cannot be reached because it exceeds the saturated vapour pressure by more than a factor of 33.
*The equation is based on rat inhalation volume while the LD50 is from mice. Even if the mice inhalation volume would be twice that of rat the LC50 inhalation would much exceed the SVP.
Justification for classification or non-classification
Based on the available information classification and labelling for acute oral, dermal and inhalation toxicity is not warranted in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008 and its amendments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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