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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 226-285-3 | CAS number: 5343-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Sensitization to skin was assessed in a Maurer Optimisation test conducted as stated in the Appraisal of the Safety of Chemicals in Food, Drugs and Cosmetics (1959) by the US association of Food and Drug Officials (Maurer, 1982). Thereby, ten male and ten female Pirbright white strain Guinea pigs received ten intradermal injections of 0.1% pentane-1,2-diol in physiological saline and in mixture with complete Bacto Adjuvant (vehicle : adjuvant, 1:1). 14 days after the last induction injection, a challenge injection of 0.1 ml , 0.1% pentane-1,2-diol in physiological saline, and another ten days later, 10% in vaseline was applied epicutaneously under occlusion for 24 hours. As result, no difference between test animals and untreated control animals was seen, so that pentane-1,2-diol did not show skin-sensitizing potency in albino Guinea pigs.
In addition to the studies with Guinea pigs, a Repeated Insult Patch Test with humans (see 7.10.4) could be taken into account for assessment. In this study, 53 of 60 volunteers finished the study, where they received nine applications of 0.2 ml of 50% pentane-1,2-diol in water for 24 h. Approximately two weeks later, a challenge application was performed and reactions were scored 24 and 72 hours post-application. As result, none of the subjects showed any sensitizing effects.
Migrated from Short description of key information:
Sensitization:
- skin: not sensitizung (Maurer Optimisation test; acc. FDA; HRIPT)
Justification for classification or non-classification
Due to the negative results in studies with Guinea pigs and human, no classification as sensitizing is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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