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Diss Factsheets
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EC number: 246-874-9 | CAS number: 25340-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The available evidence on degradation, bioaccumulation potential, and toxicity for diethylbenzene indicates that the screening criteria for persistence (P) is met, the definitive criteria for bioaccumulation potential (B) is not met, and screening criteria for toxicity (T) is not met. Based on the information described below for the relevant endpoints, the substance is not a PBT/vPvB.
Persistence assessment: The test substance is hydrolytically stable. The test substance is not readily biodegradable, though it shows some biodegradation in screening tests, consistent with an
inherent primary biodegradability description based on current OECD guidelines. Biodegradation of the test substance has been measured in several test systems. In an OECD 301B CO2 evolution test, biodegradation reached 4.7% after 28 days and 5.5% after 35 days, though the test design did not adequately address volatilization of the test substance from the test mixtures. In a BOD test, 10 to 40% biodegradation was reported.
The estimated half-life n the atmosphere for DEB based on reaction with hydroxyl radicals is 2 days using the Atmospheric Oxidation Program in EPI Suite.
Based on screening level criteria, persistence of the test substance cannot be ruled out. Thus, the test substance is assumed to meet the criteria for persistence since data are not available to conclude
otherwise.
Bioaccumulation assessment: Measured bioconcentration factors (BCFs) ranged from 320 to 629 for 2 ug/L test substance and 362 to 598 for 20 ug/L test substance in flow through test systems.
Based on the definitive criteria, the test substance is not bioaccumulative (“B”).
Toxicity Assessment: A flow-through study with rainbow trout reported a 96-hour LC50 value of 0.673 mg a.i./L. A static renewal acute toxicity test with D. magna reported a 48-hour EC50 of 2.01 mg a.i./L and an NOEC equal to 1.07 mg a.i./L.
A study with Pseudokirnereilla subcapitata (formerly known as Selenastrum capricornutum) reported 72-hour LC50 values of 1.21 and 1.0 mg/L for reduced growth rate and biomass. The 72 -hour NOEC was reported as 0.547 mg diethylbenzene/L.
Since these values are higher than the 0.1 mg/L threshold for toxicity (T), the test substance is not T.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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