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Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
adult fish: sub(lethal) effects
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
Estimation of 28 days NOEC value of test chemical by modelling Database - ECOSAR v.1.11. The ECOSAR Class Program is a computerized version of the ECOSAR analysis procedures as currently practiced by the Office of Pollution Prevention and Toxics (OPPT).  It has been developed within the regulatory constraints of the Toxic Substances Control Act (TSCA).  It is a pragmatic approach to SAR. The structure-activity relationships (SARs) presented in this program are used to predict the aquatic toxicity of chemicals based on their similarity of structure to chemicals for which the aquatic toxicity has been previously measured.  Most SAR calculations in the ECOSAR Class Program are based upon the octanol/water partition coefficient (Kow).  Various surfactant SAR calculations are based upon the average length of carbon chains or the number of ethoxylate units.
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material: Dodecanenitrile
- Molecular formula: C12H23N
- Molecular weight: 181.321 g/mole
- Smiles notation: C(CCCCCC)CCCCC#N
- InChl: 1S/C12H23N/c1-2-3-4-5-6-7-8-9-10-11-12-13/h2-11H2,1H3
- Substance type: organic
- Physical state: colourless liquid
Analytical monitoring:
not specified
Details on sampling:
No data available
Vehicle:
not specified
Details on test solutions:
No data available
Test organisms (species):
other: Fish
Details on test organisms:
No data available
Test type:
not specified
Water media type:
not specified
Total exposure duration:
28 d
Post exposure observation period:
No data available
Hardness:
No data available
Test temperature:
No data available
pH:
No data available
Dissolved oxygen:
No data available
Salinity:
No data available
Conductivity:
No data available
Nominal and measured concentrations:
No data available
Details on test conditions:
No data available
Reference substance (positive control):
not specified
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.065 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Neutral organics
Details on results:
No data available
Results with reference substance (positive control):
No data available
Reported statistics and error estimates:
No data available
Validity criteria fulfilled:
not specified
Conclusions:
The long-term toxicity of the test substance Dodecanenitrile (2437 -25 -4) to fishe is predicted using EPI Suite ECOSAR version 1.11. On the basis of effects observed in a static freshwater system during a 28 days exposure, the NOEC (No observed effect concentration) for the substance is estimated to be 0.065 mg/L for fish.
Executive summary:

The long-term toxicity of the test substance Dodecanenitrile (2437 -25 -4) to fishe is predicted using EPI Suite ECOSAR version 1.11. On the basis of effects observed in a static freshwater system during a 28 days exposure, the NOEC (No observed effect concentration) for the substance is estimated to be 0.065 mg/L for fish. Based on this value, it can be concluded that the test chemical Dodecanenitrile can be considered as toxic to freshwater fishes at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 2 category as per the CLP classification criteria.

Description of key information

The long-term toxicity of the test substance Dodecanenitrile (2437 -25 -4) to fishe is predicted using EPI Suite ECOSAR version 1.11. On the basis of effects observed in a static freshwater system during a 28 days exposure, the NOEC (No observed effect concentration) for the substance is estimated to be 0.065 mg/L for fish. Based on this value, it can be concluded that the test chemical Dodecanenitrile can be considered as toxic to freshwater fishes at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 1 category as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.065 mg/L

Additional information

The long-term toxicity of the test substance Dodecanenitrile (2437 -25 -4) to fishe is predicted using EPI Suite ECOSAR version 1.11. On the basis of effects observed in a static freshwater system during a 28 days exposure, the NOEC (No observed effect concentration) for the substance is estimated to be 0.065 mg/L for fish. Based on this value, it can be concluded that the test chemical Dodecanenitrile can be considered as toxic to freshwater fishes at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 1 category as per the CLP classification criteria.