Registration Dossier
Registration Dossier
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EC number: 204-259-2 | CAS number: 118-55-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Any other information on results incl. tables
Ames test performed on salmonella typhimurium; strain TA100, 1535, TA1537, TA98 (performed (i) without metabolic activation; (ii) with rat, liver S9 and (iii) with hamster liver S9) are all negative.
Applicant's summary and conclusion
- Conclusions:
- Ames test performed on salmonella typhimurium; strain TA100, 1535, TA1537, TA98 (performed (i) without metabolic activation; (ii) with rat, liver S9 and (iii) with hamster liver S9) are all negative.
Data on Ames test are inconclusive for the assessment of the germ cell mutagenicity of the substance.
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