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EC number: 239-590-1 | CAS number: 15541-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 - 14 November 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted in accordance with an internationally recognised method
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: data available from a preliminary range finding study identified the 48 hour EC50 as being approximately >100mg/1 and after discussions with the client, the definitive test concentrations were prepared as 0 (control), 10, 18, 32, 56 and 100mg/1.
- Sampling method: samples of the test solutions in which the daphnia were exposed were taken for analytical verification at the start of the definitive study, before and after renewal of solutions at 24 and 48 hours of the exposure period.
- Sample storage conditions before analysis: test substance specific analysis of each test concentration was carried out as soon as possible after sampling. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: for the definitive test, a 100 mg/1 stock solution of MPP was prepared in reconstituted water. The sample was stirred well to produce a homogeneous solution. The test concentrations were prepared by addition of the appropriate volume of the stock solution to the dilution water to give the required concentrations for the test.
- Controls: as for test solution but without addition of test substance
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): none used
- Concentration of vehicle in test medium (stock solution and final test solution): not applicable
- Evidence of undissolved material (e.g. precipitate, surface film, etc): none, a homogeneous solution was tested - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia
- Strain: Magna
- Source: reputable supplier
- Age at study initiation: less than 24 hours
- Method of breeding: the stocks of animals were cultured , and the tests performed, in reconstituted water, of typical hardness 156mg/l CaC03• The water was adjusted to 20 ± 1 °C, aerated until the dissolved oxygen concentration had reached a minimum of 60% air saturation and the pH stabilised between 7.8 ± 0.2.
- Feeding during test: no
- Feeding during culture: yes
- Food type: suspension of Chlorella vulgaris
- Amount:1 mg organic carbon / litre of culture water.
- Frequency: daily
ACCLIMATION
Not applicable, daphnia less than 24 hours old at study initiation - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 156mg/L CaCO3
- Test temperature:
- 20 ± 1 °C
- pH:
- 7.8 ± 0.2
- Dissolved oxygen:
- minimum of 60% of air saturation
- Salinity:
- not applicable - freshwater study
- Nominal and measured concentrations:
- Nominal: 0, 10, 18, 32, 56 and 100mg/I.
Measured: -, 0%, 7%, 22%, 58% and 80% - Details on test conditions:
- TEST SYSTEM
- Test vessel: dish covered with transparent perspex sheet
- Size/ fill volume: 50 ml capacity filled to 25ml
- Aeration: no
- Type of flow-through (e.g. peristaltic or proportional diluter): none, static test
- Renewal rate of test solution (frequency): renewed at 24 hours
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: CaCl2.2H2O (11.76g/L), MgSO4.7H2O (4.93 g/L), NaHCO3 (2.59 g/L), KCl (0.23 g/L). 25 ml of each solution combined and made to 1 litre with distilled water.
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: if necessary pH was adjusted with NaOH or HCl to give a pH of 7.8 ± 0.2
- Photoperiod: 16 hours light and 8 hours dark
- Light intensity: not reported
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
The number of immobilised Daphnia was recorded after 24 and 48 hour exposure periods.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8
- Range finding study: yes
- Test concentrations: 0 (control), 10, 18, 32, 56 and 100mg/L.
- Results used to determine the conditions for the definitive study: data available from a preliminary range finding study identified the 48 hour EC5, as being approximately >100mg/L - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: not possible to determine confidence limits
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities:
- Observations on body length and weight:
- Other biological observations:
- Mortality of control:
- Other adverse effects control:
- Abnormal responses:
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values:
- Effect concentrations exceeding solubility of substance in test medium: - Results with reference substance (positive control):
- - Results with reference substance valid? yes
24 hour EC50: 0.6 mg/L (0.5 -0.7mg/l)*
48 hour EC50: 0.3 mg/L (0.3 — 0.4mg/l)*
48 hour NOEC: 0.18 mg/L
48 hour 100% mortality: 1.0 mg/L
* denotes 95% confidence limits - Validity criteria fulfilled:
- yes
- Remarks:
- no mortality in controls. Test temperature, pH and dissolved oxygen all within acceptable limits
- Conclusions:
- The 48 hour EC50 for MPP was estimated to be >100mg/l based upon nominal concentrations.
Reference
Analysed exposure concentrations:
Nominal Concentration mg/1 |
0 |
10 |
18 |
32 |
56 |
100 |
|
Measured Concentration (mg/l) |
|||||
Time Zero |
0 |
* |
1 |
10 |
39 |
86 |
24 hours (aged solutions) |
0 |
* |
* |
3 .) |
29 |
75 |
|
|
|
|
|
|
|
24 hours (fresh solutions) |
0 |
* |
4 |
14 |
40 |
88 |
48 Hours (end of study) |
0 |
* |
* |
1 |
22 |
69 |
|
|
|
|
|
|
|
Mean Exposure Cone. |
0 |
* |
3 |
7 |
33 |
80 |
Recovery( %) of nominal |
- |
0% |
7% |
22% |
58% |
80% |
* Indicates recovery of MPP from aqueous test solutions was below the statistically derived LOD (Limit of Detection) for MPP derived from analytical measurement of the Pyrophosphate ion.
Limit of Detection = 0.19mg/l as P207 or 0.42mg/l as MPP
As can be seen from the data in the table, the percentage recovery of MPP was good from the test solutions at the highest exposure concentration, i.e. >80% recovery at 100 mg/1 for both the 0 and 24 hours freshly prepared samples. However there was some reduction in recovery after each of the 24 hour aging periods at this concentration and throughout the full concentration range. It is also noted that the percentage recovery dropped as the nominal concentrations decreased. The OECD guidelines state that if the percentage recovery calculated from the mean measured exposure concentrations is not within 20% of the nominal concentrations the mean measured concentrations should be used in the calculation of EC50 and LOEC and NOEC values. However, as the test material is clearly non-toxic to daphnia and the mean measured concentration recovery of the test material at the highest exposure concentration was equal to 80%, it is thought reasonable to state the EC50 value as greater than a nominal concentration of 100 mg/1.
Description of key information
The 48 hour EC50 for aquatic invertebrates was estimated to be >100mg/l based upon nominal concentrations.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 100 mg/L
Additional information
The results of an acute toxicity study showed MPP to be non-toxic to Daphnia magna. The 48 hour EC50 value was estimated to be >100mg/l based upon nominal concentrations. The highest no observed effect concentration (NOEC) after 48 hours was 100mg/l. The lowest test concentration that immobilised all twenty Daphnia within 48 hours could not be determined as there was 0% immobilisation at the highest test concentration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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