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Diss Factsheets
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EC number: 232-263-4 | CAS number: 7803-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study conducted during the period June 1971 to May 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Silane
- EC Number:
- 232-263-4
- EC Name:
- Silane
- Cas Number:
- 7803-62-5
- Molecular formula:
- H4Si
- IUPAC Name:
- silane
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- other: CFE and CF1, respectively.
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: nitrogen
- Details on inhalation exposure:
- No data.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Beckman Infrared 5-A spectrophotometer
- Duration of exposure:
- 1 - 4 h
- Concentrations:
- 1000, 4000, 6000, 10000 ppm
- No. of animals per sex per dose:
- 5-50 males
- Control animals:
- yes
- Details on study design:
- No data.
- Statistics:
- No data.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 9 600 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: based on 4/10 deaths at this concentration in mice
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 9 600 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: based on 0/5 deaths in rats (equivalent to >12611 mg/m³)
- Mortality:
- See Table 1.
- Clinical signs:
- other: No data.
- Body weight:
- No data.
- Gross pathology:
- No data.
- Other findings:
- No data.
Any other information on results incl. tables
Table 1 Summary of results for acute inhalation studies in rats and mice
Species | Nominal concentration (ppm) | Measured concentration (ppm) | Measured concentration (mg/l) | Exp. time (h) | Mortality | Time to death |
Rat | 1000 | - | - | 1.25 | 0/50 | - |
Rat | 4000 | - | - | 1 | 0/5 | - |
Rat | 10000 | 9600 | 12.6 | 4 | 0/5 | - |
Mouse | 6000 | - | - | 1 | 0/5 | - |
Mouse | 10000 | 9600 | 12.6 | 4 | 4/10 | 31 -45 h |
Mouse | 10000 | 9800 | 12.8 | 2 | 0/10 | - |
The mean weight gain of the 9600 ppm group appears to have been slightly inhibited during the first post-exposure week, but fully recovered at 14 days. No gross lesions due to treatment were observed at sacrifice. A gross pathological examination of the animals that died was not conducted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute inhalation study conducted using a protocol similar to OECD Test Guideline 403 prior to the introduction of GLP (reliability score 2), a concentration of 9600 ppm silane for 4 hours caused deaths in 4 of 10 mice. A concentration of 9600 ppm for 4 hours did not cause any deaths in five rats. Hence the LC50s for mice and rats were approximately 10000 ppm and >9600 ppm, respectively.
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