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EC number: 218-941-2 | CAS number: 2295-31-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from data from review article or handbbok
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of DMDM Hydantoin
- Author:
- Cosmetic Ingredient Review
- Year:
- 1 988
- Bibliographic source:
- JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY Volume 7, Number 3, 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: According to the protocol outlined in Title 16 parts 1500.3 (c)(4) and 1500.41 of the Code of Federal Regulations.
- Principles of method if other than guideline:
- The primary irritation potential of test chemical 1,3-Dimethylol-5,5-dimethylhydantoin (CAS No: 6440-58-0) was assessed in albino rabbits according to the protocol outlined in Title 16 parts 1500.3 (c)(4) and 1500.41 of the Code of Federal Regulations.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
- Cas Number:
- 6440-58-0
- Molecular formula:
- C7H12N204
- IUPAC Name:
- 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): 1,3-Dimethylol-5,5-dimethylhydantoin
- Molecular formula: C7H12N204
- Molecular weight: 188.1818 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 1,3-Dimethylol-5,5-dimethylhydantoin
- Molecular formula: C7H12N2O4
- Molecular weight: 188.1818 g/mol
- Substance type: organic
- Physical state: Solid
- Smiles notation: CC1(C(=O)N(C(=O)N1CO)CO)C
- InChl: 1S/C7H12N2O4/c1-7(2)5(12)8(3-10)6(13)9(7)4-11/h10-11H,3-4H2,1-2H3
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- No Data Available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact clipped skin
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Amount:0.5mL
concentration applied:0.1% - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 48 hours
- Number of animals:
- 6
- Details on study design:
- - Type of wrap if used: square patch made of surgical gauze
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No known signs of skin irritation were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material 1,3-Dimethylol-5,5-dimethylhydantoin (CAS No: 6440-58-0) was considered to be not irritating to both abraded and intact clipped skin of albino rabbits.
- Executive summary:
The primary irritation potential of test chemical 1,3-Dimethylol-5,5-dimethylhydantoin (CAS No: 6440-58-0) was assessed according to the protocol outlined in Title 16 parts 1500.3 (c)(4) and 1500.41 of the Code of Federal Regulations.
According to this protocol, 1,3-Dimethylol-5,5-dimethylhydantoin(volume, 0.5 ml) was applied to both abraded and intact clipped skin of albino rabbits (a minimum of 6) via a square patch made of surgical gauze (Table 6). The patches remained intact for 24 h, after which any reactions were evaluated. Subsequent evaluations were made 48 h after the initial ones. .
No known signs of irritation were observed after skin evaluation. Hence1,3-Dimethylol-5,5-dimethylhydantoin (CAS No: 6440-58-0)was considered to be not irritating to both abraded and intact clipped skin of albino rabbits.
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