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EC number: 286-283-3 | CAS number: 85203-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 211); read-across
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity to aquatic invertebrates of Octadecanoic acid, C16-20-branched alkyl esters (CAS 85203-92-5) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances 2-octyldodecyl isooctadecanoate (CAS 93803-87-3), Lauryl Oleate (CAS 36078-10-1) and (Z)-octadec-9-enyl oleate (CAS 3687-45-4) was conducted. The source substance 2-octyldodecyl isooctanoate (CAS 93803-87-3) is an ester of isooctanoate (C18 iso) and 2-octyldodecanol (C20 branched). Lauryl Oleate (CAS 36078-10-1) is specified as an ester of C18 unsaturated fatty acid and C12 fatty alcohol whereas the source substance 9-Octadecenoic acid (Z)-, 9-octadecenyl ester, (Z)- (CAS 3687-45-4) is an ester of C18 unsaturated fatty acid and C18 unsaturated alcohol. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13.
A statement from a laboratory is available indicating that the
study with the source substance 2-octyldodecyl isooctadecanoate is
technically not feasible due to substance characteristics. Acute testing
in Daphnia magna was performed by exposing organisms to Water
Accommodated Fractions (WAFs) (see study ‘Acute toxicity study in
Daphnia magna with [trade name]‘). However, it is not common practice to
use this approach in a prolonged toxicity test. The use of a column
generator with the test substance coated on an inert carrier (glass
beads or celite) is not possible as the test substance is a liquid. The
testing in a flow-through system is also no possible alternative, since
the hydrophobic character of the test substance hampers any way of
mixing with the dilution water. Based on the high hydrophobicity, there
is no analytical method sensitive enough to detect concentrations of the
test substance in water samples. As a result, it is not possible to give
any analytical support to the reproduction test with Daphnia magna. This
analytical support is essential to meet the acceptability criterion for
evidence that the actual concentration had been maintained within a 20%
window during the total test period. Owing to the fact that the test
substance is a liquid with a water solubility below detection (< 0.05
mg/L) and a log Kow of > 7, it is not possible to prepare solutions that
can be tested in a 21-day reproduction test with Daphnia magna. Further,
these characteristics support the expectation that it will not be very
likely that bioavailable concentrations of the test substance will ever
occur in the water phase, i.e. concentrations high enough to induce any
acute or chronic effects in aquatic organisms. This is further confirmed
in one GLP Guideline study according to OECD 211 performed with the
source substance (Z)-octadec-9-enyl oleate (CAS 3687-45-4). The study
was performed with the water flea Daphnia magna under semi-static
conditions. Due to the very low water solubility (< 0.05 mg/L) a limit
test with a Water Accommodated Fraction (WAF) of nominal 100 mg/L was
performed. No effects on reproduction and mortality were recorded after
21 d resulting in a NOELR (21 d) of ≥ 100 mg/L. The mortality in the
control was 0%, whereas 5% mortality was observed in the treatment. This
mortality is regarded as natural and tolerated by the test guideline.
The chemical analysis resulted in concentrations below the analytical
detection limit of 0.0423 mg/L reflecting the very low water solubility
of the test item.
The study with the source substance lauryl oleate (CAS 36078-10-1) was
performed according to OECD 211 under GLP conditions with the water flea
Daphnia magna. Five nominal concentrations up to 100 mg/L were tested in
a semi-static exposure system as Water Accommodated Fractions (WAF). No
effects on the reproduction of D. magna were observed after 21 d. One
dead animal was recorded at 50 mg/L but it was reported that it was no
substance specific effect (accident during medium change). Therefore, a
NOELR (21 d) of ≥ 100 mg/L (nominal) was derived. The chemical analysis
resulted in concentrations below the analytical detection limit of 0.005
mg/L reflecting the very low water solubility of the test item.
Based on the available results from three structurally similar source
substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5)
which is characterized by a similar ecotoxicological profile and
comparable structure, it can be concluded that the same result is
expected when testing the target substance Octadecanoic acid,
C16-20-branched alkyl esters (CAS 85203-92-5).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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