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Diss Factsheets
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EC number: 416-730-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- biodegradation in water: simulation testing on ultimate degradation in surface water
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1994-09-15 until 1994-10-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Anglian Water sewage treatment plant (Godmanchester), sample collected on 15 September 1994
- Preparation of inoculum for exposure: The sample was allowed to settle for approximately 30 minutes and the supernatant filtered through Whatman GFA coarse filter paper (first 250 ml discarded). The filtrate was maintained under aeration and used within 24 hours of collection.
- Pretreatment: none - Duration of test (contact time):
- 28 d
- Initial conc.:
- 5 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Solubilising agent (type and concentration if used): None
- Test temperature: 20 ± 1°C
- Other: Use of darkened glass bottles
TEST SYSTEM
- Culturing apparatus: The bottles were incubated in a water bath at 20 ± 1°C until removed for measurement
- Number of culture flasks/concentration: duplicate bottles at each sampling time
- Measuring equipment: Yellow Springs BOD Meter (Model 59)
SAMPLING
- Sampling frequency: At day 0, 4, 7, 11, 14, 18, 21, 25 and 28 (duplicate bottles at each sampling time)
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: yes ( 5 mg/l test substance plus 3 mg/l sodium benzoate) - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 3 mg/L
- Parameter:
- % degradation (O2 consumption)
- Value:
- 8
- Sampling time:
- 28 d
- Details on results:
- Cultures containing both test and standard substances combined showed an oxygen depletion value 12 % higher than that anticipated on the basi of results from separate cultures at Day 14. Consequentiy the test substance is not considered to have had an inhibitory effect on sewage bacteria under the conditions of this test.
- Results with reference substance:
- Sodium benzoate attained 77 % biodegradation within 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: Not readily biodegradable according to OECD criteria
- Conclusions:
- The test substance may not be termed as readily biodegradable.
There was no evidence of inhibitory effects under the conditions of this test.
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline sudy with analytical monitoring
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): The sludge collected from ten different places in Japan were combined and cultivated for one month
- Concentration of sludge: 30 mg/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Solubilising agent (type and concentration if used): no data
- Test temperature: 25 °C +/- 1°C
CONTROL AND BLANK SYSTEM
- Toxicity control: yes (Aniline) - Reference substance:
- aniline
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
Tab. 1: Percent biodegradability based on oxygen consumption
Test substance | Reference substance (aniline) | |||
day | % | day | % | |
No. 1 | 28 | -1 | 28 | 67 |
No. 2 | 28 | 0 | (7) | (62) |
No. 3 | 28 | 1 | |
Tab. 2: Percent biodegradability based on HPLC analyses. The concentrations of the test substance in the test mediums after 28 days were determined by HPLC and biodegradabilities (%) calculated.
Test substance |
|||
day | concentration (mg/L) | biodegradability (%) | |
No. 1 | 28 | 100 | 0 |
No. 2 | 28 | 100 | 0 |
No. 3 | 28 | 100 | 0 |
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Principles of method if other than guideline:
- Estimation of ready biodegradation in water using CATALOGIC v5.14.1.5 BOD 28 days MITI (OECD 301C) v.11.16
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Model calculation
- Duration of test (contact time):
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- QSAR model: based on OECD TG 301 C
- Value:
- 1
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- within parameter domain, out of structural fragment domain, within metabolic domain
- Details on results:
- Predicted value (model result):
0.01 ± 5.68E-3
Concomitant predictions :
Not ready degradable
Primary Half Life = < 1 day
Ultimate Half Life = 7y 5m 7d - Interpretation of results:
- not readily biodegradable
- Conclusions:
- The substance is not readily biodegradable. In total 18 metabolites at a quantity >=0.1% could be identified. None of these metabolites have logKow values indicative of a significant bioaccumulative potential.
Data source
Materials and methods
Results and discussion
- Transformation products:
- not measured
- Remarks:
- relevant degradation products are not expected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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