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EC number: 209-795-0 | CAS number: 593-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of test substance Methylamine hydrochloride (CAS no. 593 -51 -1). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 84, 96 and 100% degradation by O2consumption, BOD(NH3), TOC removal, test mat. analysis and HPLC parameter in 14 days.Thus, based on percentage degradation, Methylamine hydrochloride is considered to be readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound methanaminium chloride (CAS No. 593 -51 -1). If released in to the environment, 29% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of methanaminium chloride in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of methanaminium chloride in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of chemical into the sediment is less than 1% (i.e, reported as 0.0693%), indicating that the chemical methanaminium chloride is not persistent in sediment.
Biodegradation in soil
The half-life period of methanaminium chloride (CAS No. 593 -51 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 71% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of methanaminium chloride in soil is estimated to be 30 days (720 hrs). Based on this half-life value of methanaminium chloride, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various study and predicted data for the target compound methanaminium chloride (CAS no. 593 -51 -1) and 3 supporting studies (from authoritative database) for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:
In an experimental key study (J-CHECK, 2016),biodegradation experiment was conducted for 14 days for evaluating the percentage biodegradability of test substance Methylamine hydrochloride (CAS no. 593 -51 -1). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 84, 96 and 100% degradation by O2consumption, BOD(NH3), TOC removal, test mat. analysis and HPLC parameter in 14 days. Thus, based on percentage degradation, Methylamine hydrochloride is considered to be readily biodegradable in nature.
In a predicted data done using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound methanaminium chloride (CAS no. 593 -51 -1) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that methanaminium chloride is expected to be readily biodegradable.
For read across substance Monomethylamine (CAS no. 74 -89 -5), biodegradation study was conducted for evaluating the percentage biodegradability of substance Monomethylamine (HSDB, 2016). The percentage degradation of test substance was determined to be 67.8% degradation by BOD parameter in 13 days. Thus, based on percentage degradation, Monomethylamine is considered to be readily biodegradable in nature.
Another supporting biodegradation study (HSDB, 2016) was carried out for 28 days for evaluating the percentage biodegradability of the read across substance Monomethylamine (CAS no. 74 -89 -5).The study was performed according to OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test). The percentage degradation of test substance was determined to be107% by ThOD parameter in 28 days. Thus, based on percentage degradation, Monomethylamine is considered to be readily biodegradable in nature.
In an additional study of the same read acrosssubstance Monomethylamine (CAS no. 74 -89 -5) from authoritative database (HSDB, 2016), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance Monomethylamine. The study was performed according to OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test). The percentage degradation of test substance was determined to be 96% by DOC removal parameter in 28 days. Thus, based on percentage degradation, Monomethylamine is considered to be readily biodegradable in nature.
On the basis of above results for target chemical methanaminium chloride (from authoritative database J-CHECK and EPI Suite) and for its read across substance (from HSDB authoritative database), it can be concluded that the test substance methanaminium chloride can be expected to be readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound methanaminium chloride (CAS No. 593 -51 -1). If released in to the environment, 29% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of methanaminium chloride in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of methanaminium chloride in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of chemical into the sediment is less than 1% (i.e, reported as 0.0693%), indicating that the chemical methanaminium chloride is not persistent in sediment.
Biodegradation in soil
The half-life period of methanaminium chloride (CAS No. 593 -51 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 71% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of methanaminium chloride in soil is estimated to be 30 days (720 hrs). Based on this half-life value of methanaminium chloride, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance methanaminium chloride can be considered to be readily biodegradable in nature.
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