Fatty acids, C18-unsatd., dimers, compds. with coco alkylamines

Endpoint summary

Additional information

If data forFatty acid C18-unsat, dimer compd. with coco alkylamineare compared with data for the individual components certain prominent features become obvious, which can be explained by the structure of the substanceand which have an impact on the further consideration of the substance in the environment.

The substance Fatty acids C18- unsat, dimers compd. with coco alkylamine is the salt of the components Fatty acids C18-unsat, dimers (C36) and coco alkylamine (CAS:61788-46-3). Once Fatty acids C18- unsat, dimers compd. with coco alkylamineis entering the aquatic environment it is expected that the substance dissociates into its two components Fatty acids C18- unsat, dimers and coco alkylamine. Based on this assumption it is justified to evaluate both components with regard to their behavior in the environment individually.

 

Available data for theFatty acid C18-unsat,. dimer compd. with coco alkylamine:

Acute aquatox studies for fish, daphnia and algae are available.

 

Fish: In an OECD 203 test with GLP, zebrafish (Danio rerio)were exposed to Fatty acid C18-unsat,. dimer compd. with coco alkylaminefor 96 h. Due to a poor water solubility WAFs were performed in nominal concentrations of 1, 3, 10, 30 and 100 mg/L. The LC50 was determined to be of 55 mg/L.

 

Daphnia: In a new OECD 202 Daphnia magnawere exposed to Fatty acid C18-unsat,. dimer compd. with coco alkylaminefor 48 h. Due to a poor water solubility WAFs were performed in nominal concentrations. The EC50 was determined to be of 34.5 mg/L.

 

Algae: In a new OECD 201 Desmodesmus subspicatawere exposed to Fatty acid C18-unsat,. dimer compd. with coco alkylaminefor 72 h. Due to a poor water solubility WAFs were performed in loading rates of 0.10, 0.32, 1.0, 3.2 and 10 mg/L. The EC50 was determined to be of 0.39 mg/L and the EC10 was found to be 0.091 mg/L.

 

Microorganisms: A valid DIN 38412/27 (Pseudomonas Oxygen consumption test) is available. After 30 min exposure time the EC10 and the EC0 were determined to be 1800 mg/L and 1000 mg/L, respectively.

 

Available data for the components:

 

Coco alkylamine:

 

Fish: The EU risk assessment for primary amines refers for coco alkylamine to fish studies performed according to OECD 201 in which LC50 values in a range of 0.16 - 0.24 mg/L were determined.

 

Daphnia: In an OECD 202 study with Daphnia magna an EC 50 of 0.09 mg/L after48h was determined for coco alkylamine (EU risk assessment for primary amines). Additionally a long term Daphnia magna data performed in an OECD 211 study are available. After 21 d a NOEC of 0.013 mg/L was detected for coco alkylamine.

 

Algae: The EU risk assessment for primary amines describes several algae studies according to OECD 201 in Scenedesmus subspicata. After 72h the lowest EC50 was determined to be 0.16 mg/L for coco alkylamine. The NOEC was derived to be 0.06 mg/L (EU risk assessment for primary amines).

 

 

Fatty acids C18-unsat,. dimers:

The HPV consortium for Fatty acids - dimers and trimers, reports several short term studies in fish, daphna and algae performed to OECD guidelines. For all three trophic levels NOELs (no observed effect loading) of > 1000 mg/L were determined. Long term studies, however, are not available.

 

Overall conclusion for Fatty acids C18-unsat,. dimers compd. with coco alkylamine

Comparing the results of the acute aquatic tests in fish, daphnia and algae ofFatty acids C18- unsat., dimers compd. with coco alkylaminewith test results for coco alkylamine on the one hand and with test results forFatty acids C18-unsat., dimerson the other hand it is concluded that the aquatic toxicity ofFatty acid C18-unsat.,compd. with coco alkylamine due to the comparable ecotoxicity ranges is driven by the ecotoxicity potential of the coco alkylamine, whereasFatty acid C18 -unsat,. dimers are non-toxic.

 

As a consequence of this conclusion the toxic properties of Fatty acids C18-unsat,. dimers compd. with coco alkylamine will be linked to the ecotoxic properties of coco alkylamine in case data for the UVCB Fatty acids, C18 -unsat., dimers compd. with coco alkylamine are not available. As a further consequence toxic properties with regard to the terrestrial compartment are also linked to coco alkylamine.

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