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Diss Factsheets
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EC number: 202-993-8 | CAS number: 101-97-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Please refer to section 7.3 for the description of the irritation effects and to 7.4 for the description of the sensitisation effects.
Additional information
Sensitisation
Human patch tests
T. Fujii, S. Furukawa and S. Suzuki, 1972 (Yukugaku 21 (12) pg 904 -908).
In a closed human patch study the skin sensitizing potential of the test item was tested. The test was conducted with 7703 subjects suffering from dermatoses. The test item item was applicated to the upper inside of the arm. Ethanol 99% and a non-irritative cream base were used as vehicle. A concentration of 0.05 -0.5 % were applicated. Only in one subject erythema reactions were found. According to this result the test item can be considered as not sensitizing.
Skin irritation
Human patch study of T. Fujii, S. Furukawa and S. Suzuki, 1972 (Yukugaku 21 (12) pg 904 -908).
In a closed human patch study the skin irritation potential of the test item was tested. 1763 healthy male and female subjects were tested in condition 1 and 1830 subjects in condition 2. The following application way was chosen: In condition 1 the site of application was the small of back in condition 2 the upper inside of arm. Vaselinum Aldum, Unguentum Hydrophilicum were used as vehicle in condition 1 and Unguentum Simplex, Unguentum Hydrophlicum were used as vehicle in condition 2. The test item was applied in a concentration of 3 -20 % and in a concentration of 0.2 -2 %. No irritation reactions were observed in 30 subjects.
Human patch study of A.E. Katz, 1946 (The Spice Mill 69 pg 46-47)
A 24 hour closed patch test was conducted on male and female volunteers. Test material was applied undiluted to an area on the inner arm of the subjects measuring 1 cm in diameter. Immediately following application, the area was covered with an adhesive bandage for 24 hours. Reactions were read daily for 5 days. No effects, no positive irritating reactions were observed in 23 tests.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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