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Diss Factsheets
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EC number: 484-460-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitization studies on several oximes and oxime silanes have been conducted. MEKO was shown to be a skin sensitizer in guinea pig studies. Methylisobutyl ketoxime (MIBKO) was not a skin sensitizer in guinea pigs. MEKO-containing oxime silanes have produced skin sensitization reactions in guinea pigs similar to MEKO itself. Oxime silanes containing MIBKO did not produce skin sensitization in guinea pigs. These data indicate the skin sensitization potential of the oxime silanes are due to the oxime and not the silicone containing moieties. Due to the differences in skin sensitization potential between MEKO and MIBKO, the skin sensitization potential of MPKO was evaluated. Originally, we conducted a local lymph node assay (LLNA) as this is the preferred methodology. In this study, we used MEKO as the positive control. Neither MPKO nor MEKO were positive in the LLNA. Since MEKO was also negative in the LLNA, we conducted another skin sensitization study on MPKO using a guinea pig method which produced skin sensitization reactions with MEKO. MPKO was not a skin sensitizer in guinea pigs. Currently, we do not know why MEKO was negative in the LLNA. However, the LLNA methodology evaluated the induction phase but not the elucidation phase of skin sensitization. The LLNA does not appear to be an appropriate method to evaluate the skin sensitization potential of oximes. Due to the rapid hydrolysis of OS1600 to MPKO and the similarities in response between other oximes and their associated oxime silanes, it is appropriate to use the MPKO data to evaluate the skin sensitization potential of OS1600.
Migrated from Short description of key information:
Not a skin sensitizer in the guinea pig (Beuhler) or LLNA studies
Justification for classification or non-classification
MPKO, the hydrolysis product of OS1600, was not a skin sensitizer in animal models. Classification is not necessary.
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