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Diss Factsheets
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EC number: 205-275-2 | CAS number: 137-05-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
In Annex VIII of the REACH regulation, a screening test for reproduction toxicity/developmental toxicity is requested for substances produced or imported in a tonnage band of >10-100 t/a. In the case of methyl 2-cyanacrylate (MCA), a test according to OECD 422 or 421 was omitted for the following reasons:
1. Test
of the MCA monomer (substance to be registered) is technically not
feasible:
Tests in aqueous media with MCA with the intent to determine effective
concentrations or no effect concentrations cannot be performed due to
technical reasons based on the chemical properties of the monomer. In
presence of moisture, MCA polmerizes within seconds (inherent property
of MCA-based instant glues). Thus, a defined effective concentration
cannot be derived.
2. MCA
polymer induced no effects on fertility or developmental toxicity:
An indirect evaluation of potential adverse effects could be done on the
basis of tests with the MCA polymer. The polymer itself is not
bioavailable, but might be partly degraded to the MCA monomer or further
degradation products if applied orally. Based on two repeated dose
studies with rats or dogs, no effect on gonads or accessory organs were
observed up to the highest dose tested (200 mg/kg b.w./d). It should be
taken into account that application of higher doses of the MCA polymer
would not necessarily lead to higher internal doses of the MCA monomer,
which is further degraded to formaldehyde and methyl 2-cyanoacetate. In
a study with the homologue butyl 2-cyanoacrylate (BCA) polymer, weaning
rats received up to 6400 mg/kg b.w./d by food for ten days. No adverse
effect on development was observed following a 90 day observation period.
3. Exposure
is limited, no consumers are exposed:
MCA is not foreseen for consumer use, only for applications at the
industrial or professional workplace. There, strict risk management
measures (RMM) are implemented to avoid contact with skin, eyes and the
respiratory tract. These RMM are triggered by local effects, i.e. the
irritation potential of MCA. Even if MCA gets accidentally in contact
with skin, it will immediately polymerize and be no longer available for
dermal penetration. Therefore, a very low bioavailability after dermal
contact is expected.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.