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Diss Factsheets
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EC number: 232-259-2 | CAS number: 7803-49-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- BASF-Test:
Young adult laboratory mice were purchased from breeder. Several groups of 5 mice per sex and dose were treated simultaneously with preparations of the test substance in suitable vehicle. The substance was injected into the peritoneal cavity. The concentrations of the preparations were used to achieve comparable volumes per kg body weight. Group-wise documentation of clinical signs was performed over the study period of 14 days. - GLP compliance:
- no
- Remarks:
- ; GLP was not compulsory at the time the study was conducted.
- Limit test:
- no
Test material
- Reference substance name:
- Bis(hydroxylammonium) sulphate
- EC Number:
- 233-118-8
- EC Name:
- Bis(hydroxylammonium) sulphate
- Cas Number:
- 10039-54-0
- IUPAC Name:
- bis(hydroxyammonium) sulfate
- Details on test material:
- - Name of test material (as cited in study report): Hydroxylammoniumsulfat
- Analytical purity: pure grade
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg-mice
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation:
mean body weight, males: 28 g
mean body weight, females: 22 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- DOSAGE PREPARATION (w/v):
0.5 % for the 25 and 50 mg/kg bw dose group
1 % for the 100 mg/kg bw dose group
1 % for the 72.7 mg/kg bw dose group, dose volume applied: 10 ml/kg bw
2 % for the 125, 160 and 200 mg/kg bw dose group
16 % for the 1600 mg/kg bw dose group - Doses:
- 25, 50, 100, 125, 160, 200 and 1600 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose.
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing:
Animals were observed and examined for clinical signs of toxicity during the first hour following application, after 2, 4 and 5 hours and further daily on working days after dosing.
Body weights were determined prior to application of the test material.
- Necropsy of survivors performed: yes
Deceased animals and those sacrificed at the end of the observation period were necropsied.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 142 mg/kg bw
- Remarks on result:
- other: after 24 h as well as after 7 days.
- Mortality:
- No mortality occured in the 25, 50 and 100 mg/kg bw dose groups. In the 125 mg/kg bw group 3/10 animals died within the first hour after application of the test material. No further animals died until the end of the observation period on day 7. In the 160 mg/kg bw group 8/10 animals died within the first hour after application of the test material. No further animals died until the end of the observation period on day 7. In the 200 mg/kg bw group 9/10 animals died within the first hour after application of the test material. No further animals died until the end of the observation period on day 7. In the 1600 mg/kg bw group 9/10 animals died within the first hour after application of the test material. No further animals died until the end of the observation period on day 7.
- Clinical signs:
- 25 - 100 mg/kg bw:
Immediately after injection of the test material intermittent breath, abdominal position, cyanosis, closed eyelids and within intervals slight convulsions were seen. From the 3rd day onward only slight and further on no more findings were seen.
125 - 160 mg/kg bw:
Immediately after injection of the test material tremor and stretching was noted, in the 125 mg/kg bw group dyspnea and cyanosis were additionally seen, followed by exitus. After 15 minutes the surviving animals were in an abdominal position with intermittent breath and apathy. On the following day accelerated breath and unkempt fur was seen. On day 4 the surviving animals were without any findings.
200 - 1600 mg/kg bw:
Immediately after injection of the test material cunvulsions and dyspnea were seen, followed by exitus. The surviving animals was without any findings from day 3 onward. - Body weight:
- The body weight of the animals was determined prior to application of the test material only.
- Gross pathology:
- Autopsy revealed no relevant findings.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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