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Diss Factsheets
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EC number: 635-156-4 | CAS number: 109293-98-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1996-06-21 until 1995-07-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Scientifically valid study, OECD guideline study. Please refer to IUCLID section 13 for read-across justification.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Diflufenzopyr
- IUPAC Name:
- Diflufenzopyr
- Reference substance name:
- 109293-97-2
- EC Number:
- 600-910-3
- Cas Number:
- 109293-97-2
- IUPAC Name:
- 109293-97-2
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK Ltd, Manston Road, Margate, Kent, England
- Age at study initiation: 8 weeks
- Weight at study initiation: 200 - 300 g
- Housing: The holding cages were made of stainless steel sheet and wire mesh and were suspended on a movable rack.
- Diet: SDS RM1
- Water: tap water
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 18 - 24°C
- Humidity: 45 - 78 %
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: A Wright dust generator was used to produce the test atmospheres containing the dust of the test substance
- Exposure chamber volume: 5 L
- Method of holding animals in test chamber: The snout-only exposure chambers were of cylindrical form and made of aluminium alloy. The rats were held for exposure, individually, in polycarbonate restraining tubes attached at one of the ports in the cylindrical section of the chamber. The tube was tapered at one end to allow the snout only to project into the chamber. The other end was closed by insertion of an expanded plastic bung. A push rod passed through the centre of the bung and was adjustable to maintain the position of the rats during exposure.
- Source and rate of air: A supply of clean dried compressed air was connected to the dust generator and the supply pressure was adjusted to give a flow rate of 14 litres per minute measured at the generator outlet nozzle. The total chamber air supply was made up to 15 1/minute with an additional flow of 11/minute into the diluent port of the chamber.
- Method of conditioning air: The test atmosphere was passed through an elutriation column to reduce, by sedimentation, the amount of non-respirable particulate in the test atmosphere.
- Temperature, humidity: 21°C, 25 %
TEST ATMOSPHERE
- Brief description of analytical method used: Five air samples were taken from the chamber during the exposure to determine the concentration of the test substance in the chamber air by chemical analysis. Samples were collected at 30, 60, 120, 180 and 235 minutes following the equilibrium period. Each air sample was withdrawn, at 4 litres per minute, through a weighed glass fibre filter mounted in an open face filter holder. The volume of the air sample was measured with a wet-type gas meter. Two additional air samples were taken during each exposure using a Marple cascade impactor. The samples were taken approximately 1.5 and 3.5 hours after the start of exposure. The material collected on the stages of the sampler was analysed to determine the particle size distribution of the test subsrance in the test atmospheres.
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Mean analysis concentration: 2.93 mg/L
Mean gravimetric concentration: 3.14 mg/L
Nominal concentration (the nominal concentration is calculated from the amount of the test substance disperrsed and the total volume of air supplied to the exposure system): 17.5 mg/L - No. of animals per sex per dose:
- 10 animals: 5 males, 5 females
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.93 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality was observed
- Clinical signs:
- other: During exposure - There were no signs attributable to exposure to the test substance in the test rats. Soiling of the fur with as a consequence of the method of restraint was seen in control and test rats. During observation period - The only sign was exc
- Body weight:
- Reduced bodyweight or a reduced rate of bodyweight gain was seen in rats exposed to the test substance for 1 day. Subsequently, weight gain was similar to that of control rats.
- Gross pathology:
- - The lung weight to bodyweight ratios for rats exposed to the test substance were similar to those of the control rats
- There were no internal or external macroscopic abnormalities detected in rats exposed to the test substance
- No treatment-related changes were detected. - Other findings:
- Water consumption:
Water consumption was slightly increased for 2 days following exposure to the test substance. Subsequently, water consumption for test rats was similar to that of the control rats.
Any other information on results incl. tables
- The size distribution results from the chemical analysis: 3.5 µm (MMAD) and 80.8 % of respirable particles (< 7 µm)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.