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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 310-060-2 | CAS number: 102110-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles. Read-across to other silicates.
Data source
Reference
- Reference Type:
- publication
- Title:
- Sodium metasilicate hypersensitivity in BALB/c mice.
- Author:
- Karrow N.A, Guo T.L, Leffel E.K, Zhang L.X, McCay J.A, Germolec D.R, K.L.Jr White
- Year:
- 2 002
- Bibliographic source:
- Am J Contact Derm 13, 133-139
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- yes
- Remarks:
- DNFB used as positive control. Test substance applied to both sides of each ear.
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Sodium metasilicate
- IUPAC Name:
- Sodium metasilicate
- Details on test material:
- Sodium metasilicate obtained from Aldrich Chemical Company (Milwaukee, USA).
No other data presented.
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: National Cancer Institute
- Age at study initiation: 45-60 days
- Weight at study initiation: 17-20 g
- Housing: 4 animals per cage in plastic shoe box cages
- Diet (e.g. ad libitum): Agway-certified diet NIH-07 ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period:ca 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-26 C
- Humidity (%): 40-70%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 h
IN-LIFE DATES: From: To:
Study design: in vivo (LLNA)
- Vehicle:
- other: ethanol
- Concentration:
- 15%
- No. of animals per dose:
- 4
- Details on study design:
- Mice were treated for 3 days with sodium metasilicate: 1st induction 2%, 2nd induction 4%, 3rd induction 6%
- Positive control substance(s):
- other: 1-fluoro-2,4-dinitrobenzene (DNFB)
- Statistics:
- Bartlett's X2 test followed by one-way analysis of variance (ANOVA) followed by Dunnett's multiple range t-test, or by nonparametric analysis of variance and the Wilcoxon's Rank Sum test. Student's t-test was used to compare the positive control group to the positive vehicles.
Results and discussion
- Positive control results:
- >30% increase
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: Not reported
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Not reported
Any other information on results incl. tables
No significantly altered cell proliferation in the auricular lymph nodes. An unsignificant increase of 40% and 30% at the 4% and 6% soldium metasilicate concentrations were measured, respectively. The positive control induced >30 -fold increase in cell proliferation in the auricular lymph nodes.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Sensitisation of mice with 2%, 4% and 6% sodium metasilicate for 3 consecutive days did not exhibit a significant effect on cell proliferation in the auricular lymph nodes.
- Executive summary:
The sensitisation potential of sodium metasilicate in mice was tested by the local lymph node assay (Karrow et al. 2002). Sensitisation with 2%, 4% and 6% sodium metasilicate for three consecutive days did not exhibit a significant effect on cell proliferation in the auricular lymph nodes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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