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Diss Factsheets
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EC number: 310-060-2 | CAS number: 102110-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Data usable for read-across purposes have been collected on the toxicokinetics of silica and silicates, which can be used for read-across purposes have been collected. There is no need to generate specific data related to Si/FeSi silicate.
Release tests in different synthetic biological fluids show that compared to the total amount of particles loaded, between 0.06 and 10% of the Si/FeSi silicate particles sized less than 0.05 mm were dissolved/released as silicon. Significantly higher quantities of silicon were dissolved/released in Gamble's fluid (<10%) than in gastric fluid (<2%) and in phosphate-buffered saline, artificial sweat, or artificial lysosomal fluid (<0.2%) after 168 hours of exposure.
After ingestion, amorphous silicon dioxide seems to have insignificant effects on tissue or urinary silicon levels. Since silicon in different forms is ubiquitous in the environment, various foods, drinking water and beverages contain silicon. Our normal dietary intake of silicon is between 20-50 mg Si/day, and the silicon in the diet seems to be in highly bioavailable form as shown as a high proportion of dietary silicon excreted in the urine. The differences in dietary intake are likely to explain the variability in urine levels of silicon among different individuals. Although in neutral solutions, elemental silicon and amorphous silicon dioxide is slowly dissolved, in acidic solutions the dissolution of silicon and amorphous silicon dioxide is significantly impaired. Thus, e. g., in the stomach, the release of silicon from silicon particles is likely to be low, which is likely to affect the absorption from the gastrointestinal tract.
After inhalation of synthetic amorphous silicon dioxide, the lung silicon content reaches a plateau level at which elimination equates with deposition. After the cessation of exposure amorphous silica is rapidly eliminated from the lung tissue.
No significant deposition into the lymph nodes has been seen in prolonged rat exposure during the first 40 days, but after 120 days, the retention was about 31% of total deposited (and 1.5 - 2% of theoretically deposited) silica. This suggests that the involvement of lymphatic elimination is not relevant in short exposure periods/lower body burdens.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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