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EC number: 219-785-8 | CAS number: 2530-85-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-03-07 to 2002-06-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): activated sludge from a wastewater treatment plant (ARA Ergolz II, Fullinsdorf, Switzerland) treating predominantly domestic wastewater.
- Preparation of inoculum for exposure: washed once with tap water
- Concentration of sludge: 30 mg dry material per litre - Duration of test (contact time):
- 28 d
- Initial conc.:
- 102 mg/L
- Based on:
- test mat.
- Initial conc.:
- 101 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 22°C
- pH: 7.3-8.1
- pH adjusted: no
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 500 mL Erlenmeyer flasks,
- Number of culture flasks/concentration: two test substance flasks, two inoculum control flasks, two reference substance flasks, one abiotic control flask, one toxicity control flask.
SAMPLING
- Sampling frequency: 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28 days
- Sampling method: Electro-chemical analysis: as dissolved oxygen consumed CO2 is generated. The CO2 is absorbed by soda lime and the total pressure decreases in the airtight flasks. The pressure drop is detected by electrode type manometer. The consumed oxygen is replaced by electrolytically generated oxygen from a copper sulphate solution.
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: yes
- Toxicity control: yes - Reference substance:
- benzoic acid, sodium salt
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 69
- Sampling time:
- 28 d
- Details on results:
- A biodegradation rate for the test substance of 60% of the ThOD in a 10-day window within the 28-day test period was not reached.
The biodegradation of the reference substance was 82% after 14 days (84% after 28 days). This fulfils the validity criteria of the guideline.
The biodegradation of the toxicity control was 60% after 14 days. This fulfils the validity criteria of the guideline (> 25% within 14 days for test substance with no inhibitory effect).
No degradation of the test item occurred in the abiotic control under the test conditions. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- A biodegradation rate of 69% within 28 days was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP. The 10 day window was not met.
Reference
Table 1: Cumulative biochemical oxygen demand (BOD mg O2/L) and Percentage Biodegradation
Days | Test Suspension | Inoculum Blank | Reference Control | Toxicity Control | Abiotic Control | ||||||||
BOD (mg O2/L) | % Degradation | BOD (mg O2/L) | BOD (mg O2/L) | % Degradation | BOD (mg O2/L) | % Degradation | BOD (mg O2/L) | ||||||
R1 | R2 | R1 | R2 | R1 | R2 | R1 | R2 | R1 | R2 | R1 | R1 | R1 | |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
1 | 2 | 2 | 1 | 1 | 1 | 0 | 11 | 9 | 6 | 5 | 6 | 2 | 0 |
2 | 7 | 7 | 3 | 3 | 2 | 1 | 78 | 81 | 46 | 48 | 86 | 25 | 0 |
3 | 17 | 19 | 6 | 7 | 7 | 6 | 95 | 97 | 53 | 54 | 105 | 29 | 1 |
4 | 44 | 44 | 21 | 21 | 7 | 6 | 108 | 107 | 61 | 60 | 135 | 38 | 1 |
5 | 49 | 49 | 24 | 24 | 7 | 6 | 119 | 115 | 67 | 65 | 147 | 41 | 1 |
6 | 52 | 52 | 26 | 26 | 7 | 6 | 124 | 121 | 70 | 69 | 155 | 43 | 1 |
7 | 56 | 56 | 28 | 28 | 7 | 6 | 130 | 127 | 74 | 72 | 171 | 48 | 1 |
8 | 59 | 60 | 29 | 30 | 8 | 7 | 135 | 133 | 76 | 75 | 191 | 54 | 1 |
9 | 61 | 64 | 30 | 32 | 9 | 8 | 138 | 137 | 78 | 77 | 195 | 54 | 1 |
10 | 64 | 70 | 31 | 35 | 10 | 8 | 141 | 141 | 79 | 79 | 199 | 55 | 1 |
11 | 68 | 82 | 33 | 41 | 10 | 9 | 143 | 145 | 80 | 81 | 203 | 57 | 1 |
12 | - | - | - | - | - | - | - | - | - | - | - | - | - |
13 | 93 | 102 | 46 | 52 | 12 | 11 | 146 | 147 | 81 | 81 | 211 | 58 | 1 |
14 | 99 | 107 | 49 | 54 | 12 | 11 | 147 | 149 | 81 | 82 | 217 | 60 | 1 |
15 | 106 | 114 | 52 | 57 | 15 | 14 | 150 | 153 | 81 | 83 | 227 | 62 | 1 |
16 | 111 | 118 | 55 | 59 | 15 | 14 | 150 | 153 | 81 | 83 | 235 | 64 | 1 |
17 | 115 | 123 | 57 | 62 | 15 | 14 | 151 | 155 | 82 | 84 | 245 | 67 | 1 |
18 | - | - | - | - | - | - | - | - | - | - | - | - | - |
19 | 125 | 133 | 62 | 67 | 16 | 15 | 152 | 157 | 82 | 85 | 259 | 71 | 1 |
20 | 127 | 134 | 63 | 68 | 16 | 15 | 152 | 157 | 82 | 85 | 263 | 72 | 1 |
21 | 129 | 136 | 64 | 68 | 17 | 16 | 152 | 159 | 81 | 85 | 265 | 73 | 1 |
22 | 130 | 138 | 64 | 69 | 18 | 17 | 153 | 159 | 81 | 85 | 269 | 73 | 1 |
23 | 131 | 139 | 64 | 69 | 18 | 17 | 153 | 159 | 81 | 85 | 271 | 74 | 1 |
24 | 132 | 140 | 65 | 70 | 18 | 17 | 153 | 160 | 81 | 85 | 273 | 75 | 1 |
25 | - | - | - | - | - | - | - | - | - | - | - | - | - |
26 | 133 | 142 | 65 | 71 | 18 | 17 | 153 | 161 | 81 | 86 | 283 | 78 | 1 |
27 | 133 | 142 | 65 | 71 | 18 | 17 | 153 | 163 | 81 | 87 | 283 | 78 | 1 |
28 | 136 | 145 | 66 | 72 | 20 | 19 | 154 | 165 | 81 | 87 | 287 | 78 | 1 |
Mean (Day 28) | - | 69 | - | - | 84 | - | - | - |
Description of key information
Biodegradation in water screening tests: Readily biodegradable but failing the 10-day window. Once the biodegradation of the alkoxy groups is taken into account there is evidence that the methacrylate side-chain is biodegrading to some extent, but it is unlikely that the silanol hydrolysis product would meet the criteria for rapid biodegradability.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable but failing 10-day window
- Type of water:
- freshwater
Additional information
Two reliable studies are available. A study conducted according to OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test) gave a result of 69% biodegradation in 28 days (not passing the 10-day window) (Grutzner 2002). This is selected as the key study as it was the study conducted most recently.
A study conducted according to EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test) gave a result of 74% biodegradation in 28 days (not passing the 10-day window) (Enste-Diefenback 1995). This is used as a supporting study.
Based on these two studies it is concluded that the substance is readily biodegradable but failing the 10-day window.
3-Trimethoxysilylpropyl methacrylate hydrolyses within the timescale of the ready biodegradation study (1.87 h at pH 7 and 20ºC to form 3-(trihydroxysilyl)propyl methacrylate and methanol. The biodegradation observed in the study is largely attributable to the biodegradation of the methanol hydrolysis product.
Methanol is readily biodegradable (OECD 2004a). Once the biodegradation of the methanol is taken into account there is evidence that the methacrylate side-chain is biodegrading to some extent, but it is unlikely that the silanol hydrolysis product would meet the criteria for rapid biodegradability.
Reference:
OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1.
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