Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-058-5 | CAS number: 298-12-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- RCC Ltd - Zelgliweg 1 - 4452 Itingen/Switzerland
- Analytical monitoring:
- yes
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- The study was performed with zebra fish (Brachydanio rerio). The test fish were raised in the RCC Laboratories without any medication. Prior to test start, they were acclimated for one week to the test water and temperature. During holding and acclimatization until one day before the start of the test the fish were fed with a commercial fish diet (Tetra Min(r) Hauptfutter, supplied by Tetra-Werke - Germany). During the last two weeks prior to the test no fish died in the test fish batch and all fish were healthy.
From the acclimated test fish batch, 10 fish were measured at the start of the test. The mean body length of the fish was 3.3 +/- 0.07 cm (Mean +/- SD), the mean body wet weight was 0.24 +/- 0.01 g (Mean +/- SD). - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- 96 h
- Hardness:
- 1.25 mmol/L (125 as CaCo3 mg/L)
- Test temperature:
- 21-22 °C during the test period
- pH:
- The pH values in the test medium and the control ranged during the test period from 6.8 to 7.2 (the pH value after adjustement at each test item application was 7.1).
- Dissolved oxygen:
- The oxygen concentration was always 7.8 mg/L or higher and thus higher than 60 % oxygen saturation
- Nominal and measured concentrations:
- 200 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- glass aquarium with 5 liters of test medium was used for each treatment
- Aeration: the test medium and the controls were slightly aerated during the test period
- Renewal rate of test solution: during the test the fish were transferred daily into a clean test vessel with freshly prepared test medium
- No. of organisms per vessel: 7
- Biomass loading rate: less than 1 g fish wet weigt per liter
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: at the start of the test and before each test medium renewal, the test medium of nomial 200 mg/L was freshly prepared by completely dissolving 1000 mg (dosing range: 1000.0-1000.5 mg) of the test item in 5 liters of test water using satirring for 15 minutes at room temperature
OTHER TEST CONDITIONS
- Adjustment of pH: with 6.2-6.5 mL of a 1 M sodium hydroxide solution
- Photoperiod: 16-hours light t 8-hours dark period (30 minutes transition)
- Light intensity: 50-500 Lux
- Reference substance (positive control):
- yes
- Remarks:
- test water without addition of the test item
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: observations
- Details on results:
- In the control and in the test medium with the nominal concentration of 200 mg/L (= Glyoxylic acid 100.3 mg/L) all fish survived until the end of the test and no visible abnormalities were observed at the test fish. Therefore, the 96-h NOEC and the 96-h LC0 were determined to be at least 200 (100.3 ) mg/L. The 96-h NOEC and the 96-h LC0 might even be higher than this concentration, but concentration in excess of 200 (100.3) mg/L have not been tested.
The 96-h LOEC, the 96-h LC50 and the 96-h LC100 were clearly higher than 200 (100.3) mg/L. These values could no be quantified due to the absence of toxicity of Glyoxylic acid 50 % at the tested concentration.
No remarkable observation were made concerniong the appearance of the test medium. It was a clear solution throught the entire test duration. - Sublethal observations / clinical signs:
In the analyzed test medium samples from the start and end of the first and last test medium renewal periods the measured test item concentrations ranged between 103 and 114% of the nominal value. Consequently, the test water renewal ensured nearly constant concentration of the test item during the test and the reported biological results are related to the nominal test item and Glyoxylic acid (in brackets) concentration.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96-hour LC50 in Zebra fish is > 200 mg/L (Glyoxylic acid 50 % ) or > 100.3 mg/L (Glyoxylic Acid).
- Executive summary:
The acute toxicity of the test item Glyoxylic acid 50% to zebra fish (Brachydanio rerio) was determined in a 96 -hour semi-static test with a daily test medium renewal according to the EU Commission Directive 92/69/EEC, Part C.1 (1992) and the OECD Guideline for Testing of Chemicals No 203, (1992). A limit test was performed in accordance with the guideline to demonstrate the test item Glyoxylic acid 50% has no toxic effect on the test organisms at the nominal concentration of 200 mg/L and a control.
In the control and in the test medium with the nominal concentration of 200 mg/L Glyoxylic Acid 50% (= 100.3 mg/L Glyoxylic Acid) all fish survived until the end of the test and no visible abnormalities were observed at the test fish.
Therefore, the 96-hour NOEC (highest concentration tested without toxic effects after the exposure period of 96 hours), and the 96-hour LC0 were determined to be at least 200 (100.3) mg/L. the 96-hour NOEC and the 96-hour LC0 might even be higher than this concentration, but concentrations in excess of 200 (100.3) mg/L have not been tested. The 96 -hour LOEC (lowest concentration with toxic effects), the 96-hour LC50 and the 96-hour LC100 were clearly higher than 200 (100.3) mg/L. These values could not be quantified due to the absence of toxicity of Glyoxylic acid 50% at the tested concentration.
Reference
Description of key information
the 96-hour NOEC (highest concentration tested without toxic effects after the exposure period of 96 hours), and the 96-hour LC0 were determined to be at least 200 (100.3) mg/L. The 96-hour NOEC and the 96 -hour LC0 might even be higher than this concentration, but concentrations in excess of 200 (100.3) mg/L have not been tested. The 96 -hour LOEC (lowest concentration with toxic effects), the 96-hour LC50 and the 96-hour LC100 were clearly higher than 200 (100.3) mg/L. These values could not be quantified due to the absence of toxicity of Glyoxylic acid 50% at the tested concentration.
Key value for chemical safety assessment
Additional information
The acute toxicity of the test item Glyoxylic acid 50% to zebra fish (Brachydanio rerio) was determined in a 96 -hour semi-static test with a daily test medium renewal according to OECD TG 203 (1992) and GLP. A limit test was performed in accordance with the guideline to demonstrate the test item Glyoxylic acid 50% has no toxic effect on the test organisms at the nominal concentration of 200 mg/L and a control.
In the control and in the test medium with the nominal concentration of 200 mg/L Glyoxylic Acid 50% (100.3 mg/L Glyoxylic Acid) all fish survived until the end of the test and no visible abnormalities were observed at the test fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.