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Diss Factsheets
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EC number: 231-555-9 | CAS number: 7632-00-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of imipramine, nitrite and dimethylnitrosamine on reproduction in mice.
- Author:
- Anderson, L.M., Goner-Sorolla, A., Ebeling, D.
- Year:
- 1 978
- Bibliographic source:
- Research Communications in Chemical Pathology and Pharmacology Vo. 19 (2), 311 ff
Materials and methods
- Principles of method if other than guideline:
- Determination of effects on reproductive parameters, including rates of fertility and perinatal survival, litter sizes, and weanling weights.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium nitrite
- EC Number:
- 231-555-9
- EC Name:
- Sodium nitrite
- Cas Number:
- 7632-00-0
- Molecular formula:
- HNO2.Na
- IUPAC Name:
- sodium nitrate
- Details on test material:
- sodium nitrite
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- CD-1 female mice (5-6 weeks old, Charles River Breeding Farms) were housed in groups of 10 and treated as follows. Group 1 received imipramine (Bio-Craft Laboratories) thoroughly mixed (100 mg/kg) with powdered Purina Laboratory Chow. Group 2 received 1 g/l NaNO2 in their drinking water.
Group 3 received both imipramine and nitrite. Group 4 received in their water 0.1 ppm DMN diluted twice weekly from a stock solution kept cold and dark and prepared fresh monthly . All mice were housed in plastic cages with hardwood shavings and filter bonnets, in a room at 24 ± 2°C, 40% relative
humidity and a 14/10 hr light/dark cycle.
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Details on mating procedure:
- After 10 wk males were added. The females were separated to individual cages when a vaginal plug was found and treatment was continued. Near term they were inspected for births once daily, except weekends . Females showing no signs of pregnancy were returned to the males for a second fertilization.
The reproductive success of each group was measured by the number of females with surviving litters and the total number of offspring at weaning. Only in the control group did each of the 10 females have surviving offspring. Fewer offspring were weaned in the DMN-, imipramine-, and nitrite-treatment groups, compared with the controls. This effect was of statistical significance for the imipramine group and the nitrite group. However, imipramine and nitrite administered together did not have an additive adverse effect of reproduction; indeed the progeny yield in this group was not significantly different
from that in the control group, even though 1 female had no litter.
After Exp . 1 indicated potentially interesting effects of the chemicals on reproductive success, Exp. 2 was carried out to study these effects in more detail. - Duration of treatment / exposure:
- Exposure period: During mating and pregnancy
Premating exposure period (males): no data
Premating exposure period (females): 20 weanling female mice were given tap water for 1 week and then drinking water with NaNO2 at a concentration of 1000 mg/l for the next 75 days (pretreatment period).
Duration of test: about 100 days - Frequency of treatment:
- continuously
Doses / concentrations
- Remarks:
- Doses / Concentrations:
190 mg/kg b.w.
Basis:
nominal in water
- No. of animals per sex per dose:
- 20
- Control animals:
- yes, concurrent no treatment
Examinations
- Parental animals: Observations and examinations:
- preconception water consumption and weight gain, conception time, litter size, rates of stillbirth and neonatal death, histopathology of the major organs of dead pups
- Litter observations:
- histopathology of the major organs of dead pups, weaning weights and sex ratios of the offspring
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified Generation not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.