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EC number: 918-811-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation
irritating to the skin
Ocular Irritation
not ocular irritants
Respiratory Irritation
No studies were located to indicate that Hydrocarbons, C10, aromatics, <1% naphthalene is a respiratory irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29/09/1992-21/10/1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EEC Directive 84/449.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 67/548/EEC (OECD TG 404)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Farms U.K. Ltd
- Age at study initiation: 3 to 5 months
- Weight at study initiation: 3.02-3.54 kg
- Housing: singly in hanging stainless steel cages with perforated or wire-mesh flooring, animals identified by cage-labels and ear-tags
- Diet (e.g. ad libitum): Standard Rabbit Diet, S.Q.C., Special Diets Services Ltd.
- Water (e.g. ad libitum): tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 15-20
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): neat
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48, and 72 hrs
7, 14, 21 days - Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: dorsal skin
- Type of wrap if used: 6 cm² lint patch covered with a larger gauze patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 4 hrs
SCORING SYSTEM: Draize - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.9
- Max. score:
- 2
- Reversibility:
- fully reversible within: 21 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- Desquamation was noted in all animals on day 7. By day 21 all symptoms were fully reversed.
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Hydrocarbons, C9, aromatics is a mild skin irritant.
- Executive summary:
This study examined the irritation/corrosion of Hydrocarbons, C9, aromatics to rabbit skin. 0.5 ml of test substance was applied to the clipped dorsal skin of 3 male and 3 female rabbits for 4 hrs. Animals were then examined at 1, 24, 48, and 72 hrs, and 7, 14, and 21 days after the end of exposure and scored using the Draize method for signs of erythema, edema, and corrosion. Mean erythema score (24, 48, and 72 hrs) was 1.9, and the mean edema score (24, 48, and 72 hrs) was 0.0. Desquamation was noted in all animals on day 7. By day 21 all symptoms were fully reversed. Hydrocarbons, C9, aromatics, is therefore not corrosive and only mildly irritating to skin. According to EU GHS guidelines, Hydrocarbons, C9, aromatics, would be not be classified as a skin irritant.
Reference
Dermal Scores for Each Animal
Dermal Response | 1 hr | 24 hr | 48 hr | 72 hr | 7 days | 10 days | 14 days | |
TT017 M | Erythema | 1 | 2 | 2 | 2 | 1 | 1 | 0 |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
TT019 M | Erythema | 1 | 2 | 2 | 2 | 1 | 0 | 0 |
Edema | 0 | 0 | 0 | 0 | 0c | 0 | 0 | |
TT021 M | Erythema | 1 | 2 | 2 | 1 | 1 | 0 | 0 |
Edema | 0 | 0 | 0 | 0 | 0d | 0 | 0 | |
TT036 F | Erythema | 1 | 2 | 2 | 2 | 0 | 0 | 0 |
Edema | 0 | 0 | 0 | 0 | 0 | 0c | 0 | |
TT038 F | Erythema | 1 | 2 | 2 | 1 | 1 | 0 | 0 |
Edema | 0 | 0 | 0 | 0 | 0 | 0c | 0 | |
TT043 F | Erythema | 1 | 2 | 2 | 2 | 1 | 0 | 0 |
Edema | 0 | 0 | 0 | 0 | 0c | 0b | 0 |
b - slight desquamation
c - desquamation
d - reduced pliability
Summary of other skin irritation studies
End Point | Study Reference | ||||||||||||||||||||||||
REACH requirement | IUCLID Section | Study Name | Data Waiving | Waiving Justification | Species | Study Result Type | Test Guideline/Qualifier | Test Guideline/Guideline | Test Guideline/Deviations | Reliability | Rational For Reliability | GLP Compliance | Test Materials/Identity | Study Result | Reference Type | Reference Author | Reference Year | Reference Title | Bibliographic Source | Testing Laboratory | Reference Report No. | Owner Company | Company Study No. | Report Date | Data access |
8.1 Skin Irritation or Corrosion | 7.3.1 | Primary Dermal Irritation Study in the Rabbit | Rabbit | experimental result | equivalent or similar to | OECD Guideline 404 | Exposure for 24 hrs, rather than 4 hrs. | 2 | In general agreement with OECD test guideline 404. | No data | MRD-ECH-80-14 | not classifiable | study report | ANON | 1980 | Primary Dermal Irritation Study in the Rabbit | HSPA0139 | Bio/dynamics Inc. | 6301-80 | ExxonMobil Petroleum & Chemical BVBA | 80MRL23 | 31/12/1980 | yes | ||
8.1 Skin Irritation or Corrosion | 7.3.1 | Primary Skin Irritation - Rabbit | Rabbit | experimental result | equivalent or similar to | OECD Guideline 404 | Exposure for 24 hrs, rather than 4 hrs, no sex data available, 12 rabbits used, and no data reported for 48 hr time point. | 2 | Uses Draize Method which is in general agreement with OECD test guideline 404. | No data | MRD-61-14 | not classifiable | study report | ANON | 1963 | Primary Skin Irritation - Rabbit | HSPA0143 | Hazleton Laboratories, Inc. | 29890 | ExxonMobil Petroleum & Chemical BVBA | 63MRL2 | yes | |||
8.1 Skin Irritation or Corrosion | 7.3.1 | Primary Dermal Irritation Study in the Rabbit | Rabbit | experimental result | equivalent or similar to | OECD Guideline 404 | Study ended on day 7, when there was still unresolved delayed erythema. | 2 | In general agreement with OECD test guideline 404. | No data | MRD-83-208 | not irritating | study report | ANON | 1984 | Primary Dermal Irritation Study in the Rabbit | HSPA0144 | Exxon Biomedical Science, Inc. | 320804 | ExxonMobil Petroleum & Chemical BVBA | 84MRL88 | 13/04/1984 | yes | ||
8.1 Skin Irritation or Corrosion | 7.3.1 | Primary Dermal Irritation Study in the Rabbit | Rabbit | experimental result | equivalent or similar to | OECD Guideline 404 | No | 2 | In general agreement with OECD test guideline 404 - GLP. | Yes | MRD-85-734 | irritating | study report | ANON | 1986 | Primary Dermal Irritation Study in the Rabbit | HSPA0145 | Exxon Biomedical Science, Inc. | 273404 | ExxonMobil Petroleum & Chemical BVBA | 86MRL60 | 09/04/1986 | yes | ||
8.1 Skin Irritation or Corrosion | 7.3.1 | Primary Dermal Irritation Study in the Rabbit | Rabbit | experimental result | equivalent or similar to | OECD Guideline 404 | No | 1 | In agreement with OECD test guideline 404 - GLP. | Yes | MRD-89-522 | not irritating | study report | ANON | 1990 | Primary Dermal Irritation Study in the Rabbit | HSPA0146 | Exxon Biomedical Science, Inc. | 252204 | ExxonMobil Petroleum & Chemical BVBA | 90MRL97 | 02/02/1990 | yes | ||
8.1 Skin Irritation or Corrosion | 7.3.1 | Primary Dermal Irritation Study in the Rabbit | Rabbit | experimental result | equivalent or similar to | OECD Guideline 404 | Exposure for 24 hrs, rather than 4 hrs. | 2 | In general agreement with OECD test guideline 404. | No data | MRD-ECH-80-14 | not classifiable | study report | ANON | 1980 | Primary Dermal Irritation Study in the Rabbit | HSPA0138 | Bio/dynamics Inc. | 6301-80 | ExxonMobil Petroleum & Chemical BVBA | 80MRL20 | 11/07/1980 | yes | ||
8.1 Skin Irritation or Corrosion | 7.3.1 | Primary Irritation of the Skin | Rabbit | experimental result | equivalent or similar to | OECD Guideline 404 | Exposure for 24 hrs, rather than 4 hrs. | 2 | Uses Draize Method which is in general agreement with OECD test guideline 404. Summary of study only. | No data | Shellsol A | moderate irritant | study report | Coombs, AD, Blair, D, Doak, SM, Carter, BI | 1977 | The Acute Toxicity of Shellsol A | HSPA0685 | Sittingbourne Research Centre | M(T)-1-77 | Shell Chemicals Europe BV | June, 1977 | yes |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990/05/02-1990/05/15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD Guideline 405. GLP
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hazelton Research Products, Inc.
- Sex: female (6)
- Age at study initiation: 14 weeks
- Weight at study initiation: 2.48-2.75 kg
- Housing: Individually
- Diet (e.g. ad libitum): Agway Certified Diet R.C.A. Rabbit (pellets), restricted with new food each day
- Water (e.g. ad libitum): Automatic watering system, ad libitum
- Acclimation period: 15 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 65-70
- Humidity (%): 40-60
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: contralateral eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): neat - Duration of treatment / exposure:
- Test material was introduced into the lower conjunctival sac of the right eye of each animal, the upper and lower lids were gently held together for one second prior to releasing to prevent loss of material.
- Observation period (in vivo):
- 1, 4, 24, 48, and 72 hrs post instillation and once per day on days 4 and 7.
- Number of animals or in vitro replicates:
- Female (6)
- Details on study design:
- SCORING SYSTEM: Draize scale for ocular irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 1.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hrs
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hrs
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hrs
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 1.33
- Reversibility:
- fully reversible within: 48 hrs
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.17
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hrs
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1-72 hrs
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1-72 hrs
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Mean 24, 48, and 72-hour scores not specified
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Mean 24, 48, and 72-hour scores not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Mean 24, 48, and 72-hour scores not specified
- Irritant / corrosive response data:
- Redness was noted for all animals at the 1 hr observation point, for 3 animals at the 24 hr observation point, and for two animals at the 48 hr observation point. Chemosis was noted for all animals at the 1 hr observation and for 1 animal at the 24 hr observation point. Only one animal was noted in having discharge at the 1 hr time point. All animals were free of any occular irritation after the 48 hr observation. The maximum Draize score was 8 at the 1 hr time point.
- Interpretation of results:
- other: Not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the individual and mean scores of ocular irritations, test substance would not be considered an ocular irritant under either EU GHS guidelines or under the EU requirements for dangerous substances and preparations guidelines.
- Executive summary:
This study was conducted to determine the potential of the substance to cause irritation to the eye in a rabbit model system. Six rabbits were instilled with 0.1 ml of MRD-89 -522, neat. Ocular examinations occurred at 1, 4, 24, 48, and 72 hrs, and days 4 and 7 post instillation. Ocular damage was assessed and scored according to the Draize eye test. All animals survived the exposure. Maximum observed Draize score was 8. Irritation subsided as the study progressed and all animals were clear of ocular irritation after the 48 hr observation. Based on the individual and mean scores, test substance should not be considered an ocular irritant under either EU GHS guidelines or under the EU requirements for dangerous substances and preparations guidelines.
Reference
Summary of other eye irritation studies:
Chemical Name: | Hydrocarbons, C9, aromatics | ||||||||||||||||||||||||
Reference Substance: | |||||||||||||||||||||||||
CAS Number: | 64742-95-6 | ||||||||||||||||||||||||
EC Number: | 265-199-0 | ||||||||||||||||||||||||
SMILES: | |||||||||||||||||||||||||
End Point | Study Reference | ||||||||||||||||||||||||
REACH requirement | IUCLID Section | Study Name | Data Waiving | Waiving Justification | Species | Study Result Type | Test Guideline/Qualifier | Test Guideline/Guideline | Test Guideline/Deviations | Reliability | Rational For Reliability | GLP Compliance | Test Materials/Identity | Study Result | Reference Type | Reference Author | Reference Year | Reference Title | Bibliographic Source | Testing Laboratory | Reference Report No. | Owner Company | Company Study No. | Report Date | Data access |
8.2 Eye Irritation | 7.3.2 | Draize Eye Irritation Studies - Rabbits | Rabbit | Experimental result | Equivalent or similar to | OECD guideline 405 | Eyes of some animals were irrigated | 2 | Acceptable, well-documented study report in general agreement with OECD guideline 405. Not performed according to GLP. | No | MRD-61-14 | not irritating | Study report | ANON | 1961 | Draize Eye Irritation Studies - Rabbits | HSPA0147 | Hazleton Laboratories | ExxonMobil Petroleum & Chemical BVBA | 61MRL7 | yes | ||||
8.2 Eye Irritation | 7.3.2 | Ocular Irritation Study in the Rabbit | Rabbit | Experimental result | Equivalent or similar to | OECD guideline 405 | Failed to continue study to 21 days when symptoms were still present at 72 hrs. | 2 | Similar to OECD guideline 405. | yes | MRD-90-720 | not classifiable | Study report | ANON | 1990 | Ocular Irritation Study in the Rabbit | HSPA0150 | Exxon Biomedical Sciences, Inc. | 172013 | ExxonMobil Petroleum & Chemical BVBA | 90MRL166 | 12/06/1990 | yes | ||
8.2 Eye Irritation | 7.3.2 | Eye Irritation Study in Rabbits | Rabbit | Experimental result | Equivalent or similar to | OECD guideline 405 | No | 2 | Similar to OECD guideline 405. | No data | MRD-ECH-80-14 | not irritating | Study report | ANON | 1980 | Eye Irritation Study in Rabbits | HSPA0148 | Bio/dynamics Inc. | 29641 | ExxonMobil Petroleum & Chemical BVBA | 80MRL16 | 11/07/1980 | yes | ||
8.2 Eye Irritation | 7.3.2 | Eye Irritation | Rabbit | Experimental result | According to | Federal Register, 28, (110), 6.6.1963. para 191.12. Test for eye irritation. | No | 2 | Summary only of study. | No data | Shellsol A | not irritating | Study report | Coombs, AD, Blair, D, Doak, SM, Carter, BI | 1977 | The Acute Toxicity of Shellsol A | HSPA0686 | Sittingbourne Research Centre | M(T)-1-77 | Shell Chemicals Europe BV | June, 1977 | yes | |||
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is no data available for Hydrocarbons, C10, aromatics, <1% naphthalene. However, data is available for a structural analogue, Hydrocarbons, C9, aromatics and presented in the dossier. This data is read across to based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.
Skin Irritation
Hydrocarbons, C9, aromatics
A key skin irritation study (Shell, 1993) examined the irritation/corrosion of Hydrocarbons, C9, aromatics to rabbit skin. 0.5 mL of test substance was applied to the clipped dorsal skin of 3 male and 3 female rabbits for 4 hrs. Animals were then examined at 1, 24, 48, and 72 hrs, and 7, 14, and 21 days after the end of exposure and scored using the Draize method for signs of erythema, edema, and corrosion. Mean erythema score (24, 48, and 72 hrs) was 1.9, and the mean edema score (24, 48, and 72 hrs) was 0.0. Desquamation was noted in all animals on day 7. By day 21 all symptoms were fully reversed. Hydrocarbons, C9, aromatics, is therefore not corrosive and only mildly irritating to skin. According to EU GHS guidelines, Hydrocarbons, C9, aromatics, would be not be classified as a skin irritant.
In a supporting study (ExxonMobil, 2004a), 3 male rabbits were subjected to a 4 hr dermal (shaved) exposure of 0.5 mL of the test material (Hydrocarbons, C9, aromatics) under a gauze pad and a compression wrap via a semi-occluded patch. Dermal responses were evaluated at 1, 24, 48, and 72 hrs post-dosing and on Days 7, 10, and 14 according to the Draize method of scoring. Animals exhibited maximum erythema (Grade 2 and 3) at the 24 hr observation point. Edema was most severe at the 1 hr observation point for all animals (Grade 2). Effects gradually lessened until there were minimal signs of edema or erythema at Day 14. By study termination, all animals were free of adverse clinical signs.
In a second supporting study (ExxonMobil, 2004b), 3 rabbits were subjected to a 4 h dermal (shaved) exposure of 0.5 ml of the test material (Hydrocarbons, C9, aromatics) via a semi-occluded patch. Dermal responses were evaluated at 1, 24, 48, and 72 hrs post-dosing and on Days 7, 10, and 14 according to the Draize method of scoring. All animals exhibited maximal erythema and edema at the 24 h observation point with effects gradually lessening until there were no signs of edema or erythema at Day 14. By study termination, all animals were free of adverse clinical signs.
In another supporting study (ExxonMobil, 2004c), 3 male rabbits were subjected to a 4 hr dermal (shaved) exposure of 0.5 mL of the test material (Hydrocarbons, C9, aromatics) under a gauze pad via a semi-occluded patch. Dermal responses were evaluated at 1, 24, 48, and 72 hrs post-dosing and on days 7, 10, and 14 according to the Draize method of scoring. Animals exhibited maximum erythema, grade 4 at the 24 hr observation point and the erythema remained in all animals through the 72 hr time period. Edema was noted at the 24 hr to 10 day time points, with severity fluctuating from mild (grade 1, 24 hrs) to more severe (grade 3, day 7). Effects gradually lessened until all animals were free of adverse clinical signs at day 14.
Hydrocarbons, C9 aromatics can be considered to be mildly to moderately irritating to the skin, with any effects generally reversible. In addition, a study was conducted in which 26 human volunteers were dermally exposed to C9 aromatics. Results showed no evidence of aromatics being a dermal irritant to humans. Using qualitative weight of evidence reasoning, the C9 Aromatics may cause mild skin irritation, but results are insufficient to classify.
Eye Irritation
Hydrocarbons, C9, aromatics
A key study (ExxonMobil, 1990) was conducted to determine the potential of the test material (Hydrocarbons, C9, aromatics) to cause irritation to the eye in a rabbit model system. Six rabbits were instilled with 0.1 mL of the test material, neat. Ocular examinations occurred at 1, 4, 24, 48, and 72 hrs, and days 4 and 7 post instillation. Ocular damage was assessed and scored according to the Draize eye test. All animals survived the exposure. Maximum observed Draize score was 8. Irritation subsided as the study progressed and all animals were clear of ocular irritation after the 48 hr observation. Based on the individual and mean scores, test material should not be considered an ocular irritant under either EU GHS guidelines.
Respiratory Irritation
No studies were located to indicate that Hydrocarbons, C10, aromatics, <1% naphthalene is a respiratory irritant.
Justification for classification or non-classification
Skin Irritation:
Based on available read across data, Hydrocarbons, C10, aromatics, <1% naphthalene does not meet the criteria for classification for skin Irritation under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Ocular Irritation:
Based on available read across data, Hydrocarbons, C10, aromatics, <1% naphthalene does not meet the criteria for classification as ocular irritants under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
Respiratory Irritation:
There are no studies that warrant classification as a respiratory irritant under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
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