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Diss Factsheets
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EC number: 231-760-3 | CAS number: 7722-64-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The registered substance is corrosive, hence an understanding of its toxicokinentic potential - rate of absorption, systemic availability etc are based on its disintergration products - Mn2+ and Mn4 +.
With regards to Mn, oral absorption is low at approximately 5% ranging from 3 -13% as reported by published lieterature - well controlled homeostatically, dermal absorption rate is minimal while inhalation is considered as 100%/worst-case.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 5
- Absorption rate - dermal (%):
- 1
- Absorption rate - inhalation (%):
- 100
Additional information
Water-soluble (64g/l at 20dec Cel) Potassium permanganate (KMnO4) is a strong oxidant with erratic behaviour that is driven by the physical conditions of the receiving ‘body’ - in this case the stomach – its pH, and even temperature will catalyse multiple reactions resulting into different oxidation states of manganese. The duration of this reaction phase is unknown as it depends on the physical state of the receiving body.
Multiple reaction phases
- Under acidic conditions (more in-line with oral exposure/HCl stomach acid)
MnO4-+
4H++ 3e- -> MnO2(s) + 2H2O
MnO4-+ 8H++ 5e- -> Mn2++
4H2O
- Under
alkaline conditions, the half-reaction is (CRC, 1990):
MnO4- + 2H2O + 3e- -> MnO2 (s) + 4OH-
- Under aqueous solution, permanganic acid equilibrates with hydrogen ions in water, (Willhite, CC., 2013):
MnO4-+ 8H++ 5e- -> Mn2++ 4H2O
The insoluble, less bioavailable MnO2forms solids and passes through the GI tract while the Mn2+is systemically available. Ingestion of water soluble manganese salts such as MnCl2or MnSO4induced systemic toxicity at lower doses than ingestion of other insoluble forms such as MnO2(Willhite, CC., 2013). Although several other soluble manganese salts exhibiting Mn2+valency exist, MnCl2is the salt mostly used in research, mainly because of its high bioavailability.
Exposure route also plays an important role on absorption, distribution and elimination for Mn and its inorganic compounds. After reviewing more than 100 publications on Mn and its inorganic compounds, Gwaizdaet al.,(2007) concluded that while systemic bioavailability of inhaled Mn is essentially equivalent to that of intravenous injection (100%), systemic uptake of ingested inorganic Mn (e.g. chloride and oxides) was not more than 3%. The reduced bioavailability from ingested inorganic manganese has been associated to intestinal uptake regulation and hepatic elimination (IEH, 2004;Willhite, CC., 2013). These are the two primary physiological factors that dictate proportional control of systemic bioavailability for Mn and its inorganic compounds.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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