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Diss Factsheets
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EC number: 618-561-0 | CAS number: 9046-10-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-01-17 - 1979-05-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- However, limited details were provided on exposure conditions (i.e., particle size determination), test substance (i.e., purity), and animal husbandry. Only one concentration was used and exposure was for 8 hours without a justification provided.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Limited details were provided on exposure conditions (i.e., particle size determination), test substance (i.e., purity), and animal husbandry. Only one concentration was used and exposure was for 8 hours without a justification provided.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- liquid
- Details on test material:
- - Physical state: liquid
- Storage condition of test material: Room temperature
Constituent 1
- Specific details on test material used for the study:
- - Name as cited in study report: Poly[oxy(methyl-1,2-ethanediyl)], alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)
- Substance type: active
- Color: clear, amber
- Lot: Jefferson chemical company, sample no. AVS-0381, 4236-10-20a, SPC no. 1575
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Wilmington, Massachusetts
- Weight at study initiation: 209-254
- Other: The animals were observed prior to exposure to assure that they were free from abnormalities.
IN-LIFE DATES: From: 1979-01-17 To: 1979-01-31
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remarks:
- dry
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: A glass exposure chamber housed the animals.
- Exposure chamber volume: 26.5 liter
- Source and rate of air: 4.0 liters per minute
- Method of conditioning air: The test substance was placed in a 500 milliliter gas-washing bottle. Dry air, at the minimum chamber flow rate of 4.0 liters per minute, was passed through the test substance and the resultant vapor-laden air was directed, undiluted, into the exposure chamber housing the test animals.
- Temperature, humidity, pressure in air chamber: the chamber temperature during the exposure was 22 degrees C.
- Other: The flask containing the test substance, two glass tubes, and connectors were weighed before and after the exposure period. The difference in weight was equal to the amount of test substance volatilized during the exposure. The nominal concentration was calculated by dividing the weight loss by the total air flow through the chamber during the exposure period. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 8 h
- Concentrations:
- 0.74 mg/L (1.42 grams of test substance delivered in a total volume of 1920 liters of dry air)
- No. of animals per sex per dose:
- 5 animals per sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations for abnormal signs were recorded at 15 minute intervals for the first hour of exposure, hourly for the remaining seven hours of the exposure, upon removal from the chamber, at one hour post-exposure, and daily thereafter for 14 days. Individual body weights were recorded on day 0 (prior to exposure) and on Days 1, 2, 4, 7 and 14 (terminus) for all animals.
- Necropsy of survivors performed: yes; On Day 14 all animals were sacrificed (ethyl ether) and gross necropsy examinations were performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.74 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: No mortality was observed at 0.74 mg/L
- Mortality:
- No mortalities occurred.
- Clinical signs:
- other: No abnormalities were observed in any animals during the exposure. Upon removal from the chamber, one animal was observed to have dry rales. At one-hour post-exposure dry rales was noted again in the same animal. During the 14-day observation period dr
- Body weight:
- Individual body weight data showed normal weight gains in all animals except one male, which showed a somewhat depressed weight gain pattern.
- Gross pathology:
- Necropsy examinations revealed lung discoloration in nine of ten animals and kidney discoloration in six of ten animals. The frequency of lung and kidney discoloration was higher than that normally observed in Sprague-Dawley rats in this type of exposure and may have been indicative of a response to the exposure.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The acute inhalation toxicity of the test substance was evaluated in male and female rats. The LC50 was determined to be >0.74 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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