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Diss Factsheets
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EC number: 246-771-9 | CAS number: 25265-77-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Maximum 8-hr exposure with 14-day observation period
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted prior to the introduction of Good Laboratory Practices and country-specific testing guidelines. Standardized experimental methods were used to test over 300 compounds. Published results presented as a collection of data; methodology also published.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VIII
- Author:
- Carpenter CP, Weil CS and Smyth, Jr HF
- Year:
- 1 974
- Bibliographic source:
- Toxicology and Applied Pharmacology 28, 313-319 (1974)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of 6 male or female rats were exposed to an atmosphere containing the test material for up to eight hours. After termination of exposure, the animals were observed for mortality for a period of 14 days.
Test method was published in:
Smyth et al., 1962. Range-finding toxicity data: List VI. American Industrial Hygiene Association Journal 23: 95-107. - GLP compliance:
- no
- Test type:
- other: See Principles of Method below
- Limit test:
- no
Test material
- Reference substance name:
- Propanoic acid, 2-methyl-, monoester with 2,2,4-trimethyl-1,3-pentanediol
- IUPAC Name:
- Propanoic acid, 2-methyl-, monoester with 2,2,4-trimethyl-1,3-pentanediol
- Reference substance name:
- Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol
- EC Number:
- 246-771-9
- EC Name:
- Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol
- Cas Number:
- 25265-77-4
- Molecular formula:
- C12H24O3
- IUPAC Name:
- 3-hydroxy-2,2,4-trimethylpentyl 2-methylpropanoate
- Reference substance name:
- (3-hydroxy-2,2,4-trimethylpentyl) 2-methylpropanoate
- IUPAC Name:
- (3-hydroxy-2,2,4-trimethylpentyl) 2-methylpropanoate
- Reference substance name:
- Texanol Ester-Alcohol; TEXANOL; 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate
- IUPAC Name:
- Texanol Ester-Alcohol; TEXANOL; 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate
- Details on test material:
- -Name of test material (as cited in study report): Isobutyric acid, 2,2,4-trimethyl-1,3-pentanediol monoester, mixed isomers
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- Rats were exposed (whole body) to a flowing stream of vapor-laden air. The vapor-air mixture was generated by passing 2.5 liters/minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 mL of the test chemical contained in a gas-washing bottle. Inhalation was continued for time periods in a logarithmic series with a ratio of two extending from one-quarter to eight hours, until the inhalation period killing about half the number of rats within 14 days was defined.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Remarks on duration:
- With this method, inhalation periods are usually four hours unless slight toxicity necessitated a longer exposure.
- Concentrations:
- Identified only as "vapor-ladened air"
- No. of animals per sex per dose:
- 6 males or females
- Control animals:
- not specified
- Details on study design:
- Groups of six male or female albino rats were exposed to a flowing stream of vapor-laden air for up to eight hours. The atmosphere was generated by passing 2.5 L/min of dried air at room temperature through the test material contained in a glass washing bottle. Following exposure, animals were observed for two weeks. Inhalations were continued for time periods in a logarithmic series with a ratio of 2 extended from one-quarter to 8 hours, until the inhalation period killing one half of the animals within 14 days was defined.
- Statistics:
- No information
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: Maximum time for no deaths from exposure to concentrated vapors
- Exp. duration:
- 8 h
- Remarks on result:
- other: No deaths from exposure to concentrated vapors
- Mortality:
- None
Any other information on results incl. tables
No concentrations were provided in the study. Degree of lethality was expresssed by the length of exposure time that resulted in no deaths from concentrated inhalation exposure.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- An LC50 could not be determined since no mortality was observed in rats following exposure to vapor-laden air for up to eight hours. Under conditions used in this study, Texanol Ester-Alcohol was not acutely toxic by the inhalation route in rats exposed to concentrated vapors in air for up to eight hours.
Based on an absence of lethality in rats exposed to concentrated vapors in air for up to eight hours, Texanol® Ester-Alcohol is not classified for "Acute Toxicity" by the inhalation route according to GHS. - Executive summary:
In an acute inhalation toxicity study in which groups of six male or female albino rats were exposed to vapor-laden concentrations of air containing Texanol Ester-Alcohol for up to eight hours, no deaths occurred. Based on the results of this study, Texanol Ester-Alcohol is not classified for toxicity by the inhalation route at this exposure concentration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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