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Diss Factsheets
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EC number: 204-662-3 | CAS number: 123-92-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: information on methodology and results is acceptable in quality and extent; study was conducted prior to GLP and test guidelines
- Justification for type of information:
- Reference to CSR in section 13.1 for read-across justification
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Eye irritation potential was examined by placing 0.1 ml of primary amyl acetate into the eye of 6 rabbits. Eyes were examined at various times for 7 days after dosing.
- GLP compliance:
- no
Test material
- Reference substance name:
- Primary Amyl Acetate (mixture of n-pentyl acetate and 2-methylbutyl acetate)
- IUPAC Name:
- Primary Amyl Acetate (mixture of n-pentyl acetate and 2-methylbutyl acetate)
- Details on test material:
- Clear, non-viscous liquid. Charge No: 475010-135-500564.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- The animals were maintained on appropriate commercial diet and municipal water. Both were available ad libitum.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL and 0.01 mL
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- Eyes are scored at one hour, approximately 6 hours, one day, 2 days and 3 days after dosing.
- Number of animals or in vitro replicates:
- Six eyes are dosed per test volume.
- Details on study design:
- Male or female New Zealand White rabbits are dosed with volumes of 0.1, 0.01 and 0.005 ml (liquid or solid). The dose is instilled into the lower conjunctival sac of one eye per animal or is placed directly on the eye. The eyelids are held together for one second. Six eyes are dosed per test volume. The eyes are scored at one hour, approximately 6 hours, one day, 2 days and 3 days after dosing. Additional readings are made if necessary. Fluorescein (2%) staining is used to determine corneal injury before dosing and at readings after one day.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effects observed
- Remarks on result:
- other: 0.1 mL test substance applied
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effects observed
- Remarks on result:
- other: 0.1 mL test substance applied
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.4
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 d
- Remarks on result:
- other: 0.1 mL test substance applied
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: 0.1 mL test substance applied
- Irritant / corrosive response data:
- In 6 rabbit eyes, doses of 0.1 ml produced minor conjunctival irritation, but no corneal injury or iritis. Slight conjunctival irritation persisted in one eye through 3 days. At 7 days, all eyes were normal. Instillation of 0.01 ml resulted in slight conjunctival irritation in 6 eyes within one hour. Four eyes remained irritated at 6 hours, but only one had slight conjuncival irritation at 24 hours. Very slight irritation persisted in this eye through 3 days.
- Other effects:
- No additional information available.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Moderate conjunctival irritation, with no involvement of the cornea or iris, resulted from instillation of 0.1 mL primary amyl acetate into rabbit eyes. Minor, transient conjunctival irritation was observed following doses of 0.01 ml primary amyl acetate. No classification for eye irritation is required according to EU criteria based on the results of this study.
Primary amyl acetate consists of N-pentyl acetate and 2-methylbutyl acetate which are structural isomers of isopentyl acetate. Based on this molecular similarity it is assumed that isopentyl acetate will exhibit an equal or similar effect in respect of eye irritation and will accordingly not be classified as eye-irritating. - Executive summary:
The eye irritation potential was examined with rabbits. Moderate conjunctival irritation, with no involvement of the cornea or iris, resulted from instillation of 0.1 mL primary amyl acetate into rabbit eyes. Minor, transient conjunctival irritation was observed following doses of 0.01 mL primary amyl acetate.
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