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Diss Factsheets
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EC number: 204-662-3 | CAS number: 123-92-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: information on methodology and results is acceptable in quality and extent; study was conducted prior to GLP and test guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Irritation following administration of 0.5 ml to the skin of rabbits was examined.
- GLP compliance:
- no
Test material
- Reference substance name:
- Primary Amyl Acetate (mixture of n-pentyl acetate and 2-methylbutyl acetate)
- IUPAC Name:
- Primary Amyl Acetate (mixture of n-pentyl acetate and 2-methylbutyl acetate)
- Details on test material:
- Clear, non-viscous liquid. Charge No: 475010-135-500564.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The animals were maintained on appropriate commercial diet and municipal water. Both were available ad libitum except when animals were restrained.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 h
- Observation period:
- Skin reaction is scored, by the method of Draize (given below), at one hour, one day, 2 days, 3 days and possibly 7 days after dosing.
- Number of animals:
- 6 (3 males, 3 females)
- Details on study design:
- Male or female New Zealand White rabbits are dosed with 0.5 ml. The dose is applied to the clipped, intact skin under a gauze patch and is loosely covered with impervious sheeting. The test material is applied to each of 6 rabbits, which are restrained for the 4-hr contact period. Excess sample is removed after contact. Skin reaction is scored, by the method of Draize, at one hour, one day, 2 days, 3 days and possibly 7 days after dosing.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 10 d
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.6
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 d
- Irritant / corrosive response data:
- Application of 0.5 ml of primary amyl acetate to covered rabbit skin resulted in well-defined erythema on 6 of 6 animals (Table 1). Slight edema was evident on 5. By 7 days only 2 rabbits had erythema (slight), none had edema, but all 6 had desquamation. Minor desquamation persisted on 5 rabbits through 14 days.
- Other effects:
- No additional information available.
Any other information on results incl. tables
Table 1 Results of skin irritation test
Time | Mean score | |
Erythema and Eschar Formation | Edema | |
5 hours | 0.2 | 0.2 |
1 day | 2.0 | 0.5 |
2 days | 1.8 | 0.8 |
3 days | 1.2 | 0.3 |
7 days | 0.3 | 0.0 |
10 days | 0.0 | 0.0 |
14 days | 0.0 | 0.0 |
Minor desquamation was observed on days 7 - 14. It became less evident at 10 and 14 days.
Scoring was by the Draize method
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Application of primary amyl acetate (a mixture of n-pentyl acetate and 2-methylbutyl acetate) to covered skin resulted in minor irritation, not meeting the EU criteria for classification. N-pentyl acetate and 2-methylbutyl acetate are structural isomers of isopentyl acetate. Based on this molecular similarity it is assumed that isopentyl acetate exhibits an equal or similar skin irritation potential and will accordingly not be classified as irritating to the skin.
- Executive summary:
The skin irritation potential of primary amyl acetate was examined. Application of the sample to covered skin resulted in minor irritation.
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