Methyl O-(4-amino-3,5-dichloro-6-fluoropyridin-2-yloxy)acetate

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable well documented study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1995

Report date:

1995

Materials and methods

Study type:

health record from industry

Endpoint addressed:

not applicable

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

In accordance with the Dow Chemical Company Ltd and DowElanco Ltd occupational health policy and guidelines a specific health surveillance programme was undertaken with regard to the manufacture and packaging of Fluroxypyr in the United Kingdom (IIA 5.9.1/01). Base line medical examinations occurred before the start of production in 1984 at the King's Lynn site in the United Kingdom and during the first year of manufacture a six monthly review of general non-specific haematological and biochemical parameters were undertaken with specific attention to liver and kidney function. In addition, bi monthly urine examination was conducted for urinary fluoride estimation as the manufacturing process involves the use of ammonium fluoride and by product production of sodium fluoride. A register was also kept of all complaints and occurrences as was a record of concurrent exposure to other chemicals and reagents.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Methylheptyl, 0-(4-amino-3,5-dichloro-6-fluoro-2-pyridyloxy) acetate

IUPAC Name:

Methylheptyl, 0-(4-amino-3,5-dichloro-6-fluoro-2-pyridyloxy) acetate

Constituent 2

Reference substance name:

1-methylheptyl [(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy]acetate

EC Number:

279-752-9

EC Name:

1-methylheptyl [(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy]acetate

Cas Number:

81406-37-3

IUPAC Name:

1-methylheptyl [(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy]acetate

Constituent 3

Reference substance name:

Acetic acid [(4-amino-3,5-dichloro-6-fluoro-2-pyridinyl) oxy], 1-methylheptyl

IUPAC Name:

Acetic acid [(4-amino-3,5-dichloro-6-fluoro-2-pyridinyl) oxy], 1-methylheptyl

Details on test material:

no details available, human health surveilance data

Method

Type of population:

occupational

Ethical approval:

not specified

Details on study design:

Information was also specifically sought on sensitisation and allergic response to the active and there have been no positive reports.
Analysis of all the collected health data since start of manufacture in 1984 using both group data and individual employee data has not revealed any significant acute or chronic medical abnormality. This includes the examination of all haematological and biochemical parameters and data from physical examination, including lung function studies and skin examination.

Results and discussion

Results:

Information was also specifically sought on sensitisation and allergic response to the active and there have been no positive reports.
Analysis of all the collected health data since start of manufacture in 1984 using both group data and individual employee data has not revealed any significant acute or chronic medical abnormality. This includes the examination of all haematological and biochemical parameters and data from physical examination, including lung function studies and skin examination.