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Diss Factsheets
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EC number: 203-694-5 | CAS number: 109-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study but not performed under GLP. Testguideline similar to OECD test guideline, but the organism E.Coli was not tested. Substance purity not reported.
Data source
Reference
- Reference Type:
- other: Study result available in the National Toxicology Program database
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: NTP Standard Protocol
- Deviations:
- yes
- Remarks:
- The test was not conducted with E. Coli
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- The test was not conducted with E. Coli
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Pent-1-ene
- EC Number:
- 203-694-5
- EC Name:
- Pent-1-ene
- Cas Number:
- 109-67-1
- Molecular formula:
- C5H10
- IUPAC Name:
- pent-1-ene
- Details on test material:
- No indication on the purity of the test substance was reported.
Constituent 1
Method
- Target gene:
- histidine gene
Species / strain
- Species / strain / cell type:
- bacteria, other: S. Typhimurium TA97, TA98, TA100, TA1535
- Metabolic activation:
- with and without
- Metabolic activation system:
- metabolic activation enzymes and cofactors from Aroclor 1254-induced male Sprague-Dawley rat or Syrian hamster liver S9 (10 and 30%)
- Test concentrations with justification for top dose:
- 0, 100, 333, 1000, 3333, 10000 ug/plate
- Vehicle / solvent:
- Dimethyl Sulfoxide
Controls
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- other: See Details on test system and conditions
- Details on test system and experimental conditions:
- Positive control chemicals used in NTP Ames tests:
For strains tested in the absence of S9:
- TA98, 2-nitrofluorene or alternatively 4-nitro-o-phenylenediamine
- TA100 and TA1535, sodium azide
- TA97, 9-aminoacridine
For strains tested with S9:
- All strains, 2-aminoanthracene (or occasionally, sterigmatocystin)
METHOD OF APPLICATION:
preincubation
DURATION
- Preincubation period: 20 minutes
- Exposure duration: 2 days
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: S. typhimurium TA 1535, TA 97, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Remarks:
- only slight cytotoxicity was measured for 10000 ug/plate without HLI
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
See attachment in section "Attached background material".
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
According to this test, no mutagenic activity of 1-Pentene was found. - Executive summary:
Mutagenicity was tested on four S. typhimurium strains according to the NTP standard protocol (Ames test). 1-Pentene was not found to be mutagenic to bacteria, with and without metabolic activation.
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