Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 300-339-7 | CAS number: 93925-37-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
The LC50 for adult mortality on Day 21 was 871 mg/kg dry soil (95 % confidence interval 783 mg/kg dry soil to 978 mg/kg dry soil). The NOEC was 560 mg/kg dry soil. The EC50 for the number of juveniles on Day 42 was 278.4 mg/kg dry soil (95 % confidence interval 164.9 to 470.0 mg/kg dry soil). The NOEC was 100 mg/kg dry soil (OECD 220).
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 278.4 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 100 mg/kg soil dw
Additional information
GUIDELINE
A study was performed to assess the effects of the test item on the reproductive output of the enchytraeid wom Enchytraeus albidus in an artificial soil under laboratory conditions. The method followed was that described in OECD Guideline for the testing of Chemicals (2004) No 220, Enchytraeid Reproductive Test.
METHOD
Eleven groups of worms were allocated to the study and eight groups of 40 worms were treated with test item at 20, 35, 60, 100, 175, 315, 560 and 1000 mg/kg dry soil. The three groups of 80 worms were water control, solvent control and a positive control group treated with Mascot Systemic (active ingredient carbendazim) at 1.2 mg/kg dry soil. Adult worms were removed from the soil on Day 21 and the juvenile worms were reared until Day 42.
RESULTS
Adult mortality was reported as 0 % (20, 35, 60, 100, 175 and 315 mg/kg dry soil), 10 % (560 mg/kg dry soil) and 67.5 % (1000 mg/kg dry soil) compared to 2.5 % in the solvent and water control groups and 23.8 % in the positive control group. The mean number of juveniles produced was 144.0 (20 mg/kg dry soil), 121.8 (350 mg/kg dry soil), 99.8 (60 mg/kg dry soil), 92.3 (100 mg/kg dry soil), 86.5 (175 mg/kg dry soil), 80.3 (315 mg/kg dry soil), 43.5 560 mg/kg dry soil) and 25.0 (1000 mg/kg dry soil). The mean number of juveniles produced was 136.0 in the solvent control group and 153.4 in the water control group. A mean of 3.8 juveniles was produced in the positive control group.
Reduction in the number of juveniles was calculated as 0, 10.4, 26.6, 32.1, 36.4, 41.0, 68.0 and 81.6 % at test item treatment rates of 20, 35, 60, 100, 175, 315, 560 and 1000 mg/kg dry soil compared to the solvent control. Statistically significant reductions were observed at 175 and 315 mg/kg dry soil (0.004**) and 560 and 1000 mg/kg dry soil (p < 0.001***).
The study was considered valid as there was ≤ 20 % adult mortality at Day 21 and ≥ 25 juveniles had been produced in each control replicate by the end of the test with the coefficient of variation of reproduction ≤ 50 %. In addition, application of the toxic reference (carbendazim applied at 1.2 mg/kg dry soil) resulted in substantial and unequivocal toxic effects.
CONCLUSION
The LC50 for adult mortality on Day 21 was 871 mg/kg dry soil (95 % confidence interval 783 mg/kg dry soil to 978 mg/kg dry soil). The NOEC was 560 mg/kg dry soil. The EC50 for the number of juveniles on Day 42 was 278.4 mg/kg dry soil (95 % confidence interval 164.9 to 470.0 mg/kg dry soil). The NOEC was 100 mg/kg dry soil.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.