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EC number: 500-537-5 | CAS number: 161075-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 2013 to March 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD Guideline-conform study conducted under GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5.58
- Temp.:
- 20 °C
- pH:
- 5.3
- Remarks on result:
- other:
- Remarks:
- pH of the aqueous phase (water HPLC grade) was measured at the end of the Kow determination.
- Details on results:
- The whole procedure was conducted at room temperature (ca. 20°C) and the pH value of the aqueous phase was 5.3.
- Conclusions:
- The test item showed grater affinity for n-octanol than for water. The mean Log Kow calculated basing on the experimental data was 5.58.
- Executive summary:
The Partition Coefficient n-Octanol-water of the test item was determined under GLP according to OECD guideline No. 107 and EU method A.8, Partition Coefficient (n-octanol / water), Shake Flask Method.
In the preliminary test, in order to prepare a 0.01 M solution as suggested by A.8 method, and considering the molecular weight = 400 g/mol for the test item, a 4.0 g/L solution was prepared in the n-octanolic phase saturated with water derived from the original equilibrated mixture.
A solution containing a target concentration of 4197.6 microgram/mL, taking into account its 99 % purity, was prepared weighting the test item and dissolving it in the n-octanolic phase (saturated with water).
Three tests, using different ratios of the two phases (1.1, 1:2, 2:1 ) were performed. For each ratio, duplicate test vessels were prepared.
The test vessels were shaken for 2 hours on a mechanical shaker; that time elapsed, the two phases were separated by a 250 mL separatory funnel and analyzed by GC coupled with a FID detector. Calculations of analytical concentrations were made by an external standard.
All the procedure was conducted at room temperature (ca. 20 °C) and the pH value of the aqueous phase was 5.3.
The test item showed greater affinity from octanol than for water. Basing on the experimental data the mean Kow was calculated to be 384702.9 (RSD = 4.11%) and mean Log Kow was calculated to be 5.58 (RSD = 0.32 %).
Reference
Ratrio O:W | Test vessel | Test item concentration in water (microgram/L) | Test item concentration in octanol (microgram/L) | Kow | mean Kow | mean Log Kow |
1:1 | A | 10,18 | 10180000,00 | 384066,80 | 397378,049 | 5.599 |
B | 9,72 | 9720000,00 | 410689,30 | |||
1:2 | A | 10,50 | 10500000,00 | 368314,29 | 368393,3857 | 5.566 |
B | 10,54 | 10540000,00 | 368472,49 | |||
2:1 | A | 10,27 | 10270000,00 | 384985,39 | 388279,7342 | 5.589 |
B | 9,72 | 9720000,00 | 391574,07 | |||
Mean: | 384702.9 | 5.58 | ||||
RSD%: | 4.11% | 0.32% |
Description of key information
The experimental determination of the partition coefficient Kow of GALDEN LMW was carried out according to the shake-flask method described in the OECD Guideline No. 107.
Log Kow of GALDEN LMW is 5,58.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.58
- at the temperature of:
- 20 °C
Additional information
Galden is a multi-constituent substance consisting of low molecular weight perfluoropolyethers (PFPE). Two grades of Galden LMW are manufactured (Galden HT55 and Galden HT70), which contain the same perfluorinated constituents and differ only in the relative concentration of the constituents.
As the two grades both contain only perfluorinated constituents (albeit in different relative concentrations), the solubility properties of both Galden grades are very similar. The log Kow= 5.58 therefore is representative for both grades.
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