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Diss Factsheets
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EC number: 919-274-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 14 August 2007 to 20 September 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- Sponsor's identification: AS305BD
Description: dark brown, viscous liquid
Lot number: TS07002
Analytical purity: 100%
Storage conditions: room temperature in the dark
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Portage MI and Kingston, NY
- Age at study initiation: 8-9 weeks
- Weight at study initiation: 158-183 g prior to dosing
- Housing: suspended stainless steel cages
- Diet (e.g. ad libitum): PMI Certified Rodent Chow #5002 ad libitum (except during fasting)
- Water: municipal tap water ad libitum
- Acclimation period: minimum of five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-21 degrees C
- Humidity (%): 40-77 %
- Air changes (per hr): 10-15 air changes/hour
- Photoperiod (hrs dark / hrs light): 12 hr light/12 hr dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The test article was administered as 30 mg/mL and 200 mg/mL mixtures w/v in corn oil and dispensed on the day of dosing. The mixtures were stirred continuously during dosing.
- Doses:
- Single oral administration of the test article at the dose levels of 300 and 2000 mg/kg. Individual doses were calculated on basis of animal's fasted body weight.
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical observations - twice on day 0 and daily thereafter; bodyweights - prior to fasting (day -1), prior to dosing (day 0), days 7 and 14.
- Necropsy of survivors performed: yes (body cavities were opened and examined; no tissues were retained). - Statistics:
- Based on the results of each dose level, the LD50 was estimated as follows:
- <50% mortality - LD50 was estimated as greater than the administered dose
- =50% mortality - LD50 was estimated as equal to the administered dose
- >50% mortality - LD50 was estimated as less than the administered dose
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None
- Clinical signs:
- The following clinical observations were noted at the 300 mg/kg dose - decreased activity, few feces, diarrhea, urine staining, sailvation and congested breathing.
The following clinical observations were noted at the 2000 mg/kg dose - decreased activity, few feces, soft stools, mucoid stools, no feces, fecal staining, urine staining, dark material around facial area, breathing abnormalities, unkempt appearance, rough coat, and cool to touch - Body weight:
- All animals gained body weight during the test period.
- Gross pathology:
- No gross internal findings were observed at necropsy on study day 14
- Other findings:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this test, the acute oral LDso of AS305BD was estimated to be greater than 2000 mg/kg in the female rat.
- Executive summary:
In line with OCED Guideline 423, the oral toxicity of AS305BD was evaluated in rats. A limit test was performed in which three female rats received a single oral administration of 300 mg/kg bodyweight. As no mortality was recorded, three further animals received the same dose. A second limit test was subsequently performed in which three female rats received a single oral administration of 2000 mg/kg bodyweight. As no mortality was recorded, three further animals received the same dose.
No mortality occurred during the study although clinical observations were made in animals at both doses. All animals gained bodyweight during the study. No gross internal findings were observed at necroscopy.
Under the conditions of the test, the acute oral LD50 of AS305BD was estimated to be > 2000 mg/kg in the female rat.
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