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EC number: 609-336-8 | CAS number: 371756-75-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 65 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 37 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Systemic Effects:
Disodium 4,4'-bis[(4-anilino-6-morpholino-1,3,5-triazin-2-yl)-amino]stilbene-2,2'disulphonate (CAS 16090 -02 -1) is a technical product which belongs to the category of stilbene fluorescent whitening agents. This substance and all other members of this category do not show acute toxic effects after oral, inhaltory, and dermal administration. Reading across, it is assumed that also the substance CAS 371756 -75 -1 does not show acute toxic effect after oral, inhaltory, and dermal administration.
They are neither irritant to skin nor eyes, nor genotoxic in-vitro and in-vivo nor sensitzing. In the 28-day subchronic and 24 month chronic toxicity study in the rat, no treatment-related clinical symptoms and no signs of systemic toxicity were observed throughout the study. The only study that showed systemic findings was the two-generation study with bolus dosing of 1000 mg/kg bw. These findings involved the kidneys and this is considered to be related to bolus dosing. For hazard assessment, the two-year feeding study in rats with continous exposure is considered to be most relevant. Since no treatment related adverse effects were observed, the dose level of 791 mg/kg bodyweight per day for females and a dose level of 524 mg/kg bw/day for male is regarded to represent the "no observed adverse effect level" (NOAEL) for this test article and all other category members. The average NOAEL is therefore 658 mg/kg bw/day. The DNELs for inhalation and dermal long-term exposure are derived from the no observed effect level obtained from this oral repeated dose toxicity study with this substance. In general, the calculation of DNEL is based on the observed effect level which has to be modified. To correct the interspecies difference between rat and human the no observed effect level has to be corrected as follows:Corrected starting point for the inhalative route for workers: = NOAEL * (1/0.38 m³/kg bw) * 6.7 m³/10 m³* (7/5) (0.38 m³/kg bw: default respiratory volume for the rat corresponding to the daily duration of human exposure. For workers a correction is needed for the difference between respiratory rates under standard conditions and under conditions of light activity. Since worker are exposed 5 days per week and the rats were exposed 7 days per week a factor 7/5 was included.). Thus, the corrected starting point for workers was 1624.2 mg/m³/d for inhalation. Subsequently other assessment factors are listed, which have to be taken into account for the final DNEL calculation: remaining differences (2.5), intraspecies differences: worker (5). For difference of absorption, a factor of 2 is included. This results in an overall assessment factor of 25. The DNEL for long-term inhalative exposure, systemic effects is therefore 65 mg/m³.
Corrected starting point for the dermal route for workers: = NOAEL/0.5*(7/5) = 1842.4 mg/kg bw/day (An additional assessment factor (0.5) was used to consider the difference in dermal absorption properties of human and rat skin. Since worker are exposed 5 days per week and the rats were exposed 7 days per week a factor 7/5 was included.). Subsequently, following assessment factors are taken into account for the final DNEL calculation of systemic dermal effects: interspecies differences: human-rat (4), remaining differences (2.5), intraspecies differences: worker (5). This results in an overall assessment factor of 50. The resulting DNEL for long-term dermal systemic effects for the Stilbene fluorescent whitening agents was 37 mg/kg bw/d for workers.General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 11.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 13 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 6.6 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Stilbene fluorescent whitening agents do not show acute toxic effects after oral, inhaltory, and dermal administration. They are neither irritant to skin nor eyes, nor genotoxic in-vitro and in-vivo nor sensitzing. In the 28-day subchronic and 24 month chronic toxicity study in the rat, no treatment-related clinical symptoms and no signs of systemic toxicity were observed throughout the study. Since no treatment related adverse effects were observed a dose level of 791 mg/kg bodyweight per day for females and a dose level of 524 mg/kg bw/day for male is regarded to represent the "no observed adverse effect level" (NOAEL) for this test article and all other category members. The combined NOAEL is therefore 658 mg/kg bw/day. The DNELs for inhalation and dermal long-term exposure are derived from the no observed effect level obtained from this oral repeated dose toxicity study with this substance. In general, the calculation of DNEL is based on the observed effect level which has to be modified. To correct the interspecies difference between rat and human the no observed effect level has to be corrected as follows:
Corrected starting point for the inhalative route for general population: =NOAEL * (1/1.15 m³/kg bw/day) (1.15 m³/kg bw/day: default respiratory volume for the rat corresponding to the daily duration of human exposure. Thus, the corrected starting point for the general population was 572.2 mg/m³ for inhalation. Subsequently other assessment factors are listed, which have to be taken into account for the final DNEL calculation: remaining differences (2.5), intraspecies differences: general population (10). A factor of two is introduced to allow for potential differences in absorption. The DNEL for long-term inhalative exposure, systemic effects is therefore considered to be 11.5 mg/m³.
Corrected starting point for the dermal route for general population: = NOAEL/0.5 = 1316 mg/kg bw/day (An additional assessment factor (0.5) was used to consider the difference in dermal absorption properties of human and rat skin.) Subsequently, following assessment factors are taken into account for the final DNEL calculation of systemic dermal effects: interspecies differences: human-rat (allometric scaling factor of 4), remaining differences (2.5), intraspecies differences: general population (10). The resulting DNEL for long-term dermal systemic effects of stilbene fluorescent whitening agents was 13 mg/kg bw/d for general population.
Corrected starting point for the oral route for general population: = NOAEL = 658 mg/kg bw
Subsequently, following assessment factors are taken into account for the final DNEL calculation of systemic dermal effects: interspecies differences: human-rat (allometric scaling factor of 4), remaining differences (2.5), intraspecies differences: general population (10). The resulting DNEL for long-term oral systemic effects of Stilbene fluorescent whitening agents was 6.6 mg/kg bw/d for general populationInformation on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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