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EC number: 221-209-5 | CAS number: 3031-66-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, predated OECD guideline, but scientifically fully acceptable and well documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF- Test:acute inhalation toxicity with rats exposed to a saturated atmosphere for max. 8h
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hex-3-yne-2,5-diol
- EC Number:
- 221-209-5
- EC Name:
- Hex-3-yne-2,5-diol
- Cas Number:
- 3031-66-1
- Molecular formula:
- C6H10O2
- IUPAC Name:
- hex-3-yne-2,5-diol
Constituent 1
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Remarks:
- 200 L/h
- Analytical verification of test atmosphere concentrations:
- no
- Remarks on duration:
- 1 - 8 h
- Concentrations:
- saturated atmosphere
- No. of animals per sex per dose:
- 20°C: 12 for the 8-hour exposure
40°C: 12 for the 1-hour exposure, 6 for the 3-hour exposure and 6 for the 8-hour exposure - Control animals:
- no
- Details on study design:
- The test substance was offered as a vapour at 20°C resp. 40°C.
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- other: Lethality
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: Mortality 0/12 (40°C)
- Sex:
- not specified
- Dose descriptor:
- other: Lethality
- Based on:
- test mat.
- Exp. duration:
- 3 h
- Remarks on result:
- other: Mortality 3/6 (40°C)
- Sex:
- not specified
- Dose descriptor:
- other: Lethality
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: Mortality 6/6 (40°C)
- Mortality:
- 20°C: no deaths after 8 hours.
40°C: no deaths after 1-hour exposure, 3 animals died after 3-hour exposure and all (6) animals died after 8-hour exposure. - Clinical signs:
- other: Attemption to escape, irritation of the mucous membrane at 20°C. Attemption to escape, irritation of the mucous membrane, dyspnea, apathy, staggering and tremor at 40°C.
- Gross pathology:
- Pulmonary congestion, congestion in the liver, degeneration of the liver, heart dilatation.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.