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EC number: 202-696-3 | CAS number: 98-73-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is contained in EU risk assessment report of the substance - credibility is assumed. Reference to origin (HRC (1994, 1995))
Data source
Referenceopen allclose all
- Reference Type:
- other: EU risk assessment report
- Title:
- No information
- Author:
- Federal Institute for Occupational Safety and Health, Division for Chemicals and Biocides Regulation, Germany
- Year:
- 2 009
- Bibliographic source:
- European Union Risk Assessment Report, 4-tert-butylbenzoic acid, CAS No: 98-73-7, EINECS No: 202-696-3, p. 54, Final Approved Version, July 2009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
- Principles of method if other than guideline:
- 5-day and 28-d repeated dose inhalation toxicity study using rats (male/female), snout-only exposition to test substance, subsequent examination of substance-induced effects
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butylbenzoic acid
- EC Number:
- 202-696-3
- EC Name:
- 4-tert-butylbenzoic acid
- Cas Number:
- 98-73-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 4-tert-butylbenzoic acid
- Test material form:
- other: particulate aerosol generated from micronised test substance powder (MMAD 4.1-4.4 µm, ≥ 65 % MMAD < 7 µm).
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: snout-only
- Vehicle:
- air
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
There were no clinical signs, bodyweight changes, effects on food and water consumption, macroscopic pathology findings or differences in organ weights that were considered to be attributable to exposure to PTBBA. Samples of a number of organs were preserved, but not prepared for microscopic pathology (HRC, 1994).
Liver weights of high dose females were significantly higher than control values (+9%). There were no other clinical signs, bodyweight changes, effects on food consumption, macroscopic or microscopic changes in main study rats that were attributable to p-tert butyl benzoic acid. Behavioural observations revealed a slight increase in the incidence of body tremor in the low and high dose group males after 1 week of exposure. After 4 weeks the incidence of body tremor was increased for high dose males. Among high dose males, there was a significant decrease in activity counts with tendency towards decreased rearing counts. Also, facial staining and hair loss occurred with slightly increased frequency in high dose males. The number of males with decreased arousal and urinating/defecating while in the arena was increased in the mid and high dose groups. No similar findings were noted among treated females. Neither the microscopic examination of the organs examined in the main study nor the examination of the nervous tissues in satellite rats revealed any lesions, which were attributable to 4-tert-butylbenzoic acid. The occurrence of body tremor might be considered as the most sensitive and earliest neurobehavioural effect. Since no behavioural change was noted for low dose males after 4 weeks of exposure and no body tremor was observed for mid dose males, the NOAEC was considered to be 5 mg/m³ for male rats. The authors proposed a NOAEC of 15 mg/m³ for female rats. Based on the knowledge that the liver was a target organ in other repeated dose studies, the rapporteur’s opinion is that due to increased liver weight 5 mg/m³ should also be considered as the NOAEC for female rats. (HRC, 1995)
Applicant's summary and conclusion
- Conclusions:
- According to the results of this study the inhalation NOAEC for the test substance is 5 mg/m³.
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