N-(2-ethoxyphenyl)-N'-(2-ethylphenyl)oxamide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1974

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only summary available - no detailed assessment possible

Data source

Reference

Reference Type:

other: study report summary

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

other: US Hazardous Substance Act version April 1st 1973

Deviations:

no

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

only 1 hour exposure rather than 4 hours

GLP compliance:

no

Remarks:

pe-dates GLP requirements

Test type:

fixed concentration procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Sanduvor VSU

IUPAC Name:

Sanduvor VSU

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

CAS-No.: 23949-66-8
EINECS-No.: 245-950-9
Formula: C18H20N2O3

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Details on test animals or test system and environmental conditions:

no further details provided in summary

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

20 animals were exposed to an air stream containing 5 mg/L test material as dust for one hour. Some animals were sacrificed immediately following exposure and their respiratory organs were assessed histopathologically. The remaining animals were kept for 14 days of the recovery period.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

Concentrations:

5 mg/L

No. of animals per sex per dose:

20 males

Control animals:

no

Statistics:

no statistics applied due to lack of mortality

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

> 5 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

1 h

Remarks on result:

other: no mortality occured

Mortality:

no mortality occured

Clinical signs:

other:

Body weight:

not examined

Gross pathology:

no data provided in summary

Other findings:

Mild signs of irritation of eyes and upper respiratory tract of transient nature were observed during exposure period which were fully reversible during the 14 day recovery period.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

LC50 (rat, 1h, dust/mist): > 5 mg/L in air

Executive summary:

When exposed at 5 mg/L in air to rats for one hour, no mortality was observed, but some animals showed mild signs of irritation of eyes and the upper respiratory tract. These irritation symptoms were of transient nature and disappeared within the recovery period of 14 days entirely.