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EC number: 205-575-3 | CAS number: 142-96-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Concentration-dependent elicitation of dermal sensitization in guinea pigs treated with 2,4-toluene diisocyanate
- Author:
- Koschier, F.J., Burden, E. J., Brunkhorst, C.S., Friedman, M.A.
- Year:
- 1 983
- Bibliographic source:
- Toxicol. Appl. Pharmacol., 67, 401-407
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- not specified
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Type of study:
- open epicutaneous test
- Justification for non-LLNA method:
- Other study available.
Test material
- Reference substance name:
- Dibutyl ether
- EC Number:
- 205-575-3
- EC Name:
- Dibutyl ether
- Cas Number:
- 142-96-1
- Molecular formula:
- C8H18O
- IUPAC Name:
- 1-butoxybutane
- Details on test material:
- dibutyl ether (purity not indicated)
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- not specified
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: commercial breeder
- Age at study initiation: young adults
- Housing: Animals were housed individually in stainless steel cages with wire mesh bottoms
- Diet (e.g. ad libitum): certified guinea pig chow 5026 (ralson Purina Co.) was available ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2°C
- Humidity (%): 40 - 60%
- Photoperiod (hrs dark / hrs light): 12 hours each cycle
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- other: no vehicle used
- Concentration / amount:
- The animals received a total application of 50 µl dibutyl ether with each animal receiving two 25 µl amounts on separate sites
Challenge
- Route:
- epicutaneous, open
- Vehicle:
- other: no vehicle used
- Concentration / amount:
- The animals received a total application of 50 µl dibutyl ether with each animal receiving two 25 µl amounts on separate sites
- No. of animals per dose:
- 5
- Details on study design:
- 1st application: Induction 50 µl other: two 25 µl applications undiluted open epicutaneous
2nd application: Challenge 150 µl other: six 25 µl applications undiluted open epicutaneous
3rd application: Challenge 150 µl other: six 25 µl applications undiluted open epicutaneous
Young adult guinea pigs (strain Hartley, received from commercial breeders) were housed individually in stainless-steel cages with wire-mesh bottoms in temperature (21 ± 2 °C) and humidity-controlled (40 - 60 %) rooms. Twelve hours of continuous fluorescent lighting was provided daily. Certified guinea pig chow 5026 (Ralson Purina Co.) and water were available ad libitum. The hair on the dorsum was clipped 24 hours before exposure. For induction, the animals received a total application of 50 µl undiluted dibutyl ether with each animal receiving two 25 µl amounts on separate sites. Five days later, each guinea pig received on virgin sites six challenge applications of 25 µl undiluted aliquots. A rechallenge was performed 9 days after the first challenge. Skin reaction was scored by the method of Draize at 24 and 48 hours after application - Challenge controls:
- no information available
- Positive control substance(s):
- no
Results and discussion
- Positive control results:
- None
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 25 µl of the undlluted test substance
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 25 µl of the undliuted test substance
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 25 µl of the undliluted test substance
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- rechallenge
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 25 µl of the undliluted test substance
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Key result
- Group:
- negative control
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
The animals did not respond with dermal hypersensitivity reactions when challenged with dibutyl ether. The mean scores 24 hours after day 5 and day 14 challenge were 0.8 and 0.0, respectively. No individual scores were greater than 1.0 (maximum possible score of 8). According to these results, dibutyl ether has no sensitization potency.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the animals did not respond with dermal hypersensitivity reactions when challenged with dibutyl ether. The mean scores 24 hours after day 5 and day 14 challenge were 0.8 and 0.0, respectively. No individual scores were greater than 1.0 (maximum possible score of 8). According to these results, dibutyl ether has no sensitization potency.
- Executive summary:
The skin sensitization potential of dibutyl ether was evaluated in guinea pigs. Young adult guinea pigs (strain Hartley, received from commercial breeders) were housed individually in stainless-steel cages with wire-mesh bottoms in temperature (21 ± 2 °C) and humidity-controlled (40 - 60 %) rooms. Twelve hours of continuous fluorescent lighting was provided daily. Certified guinea pig chow 5026 (Ralson Purina Co.) and water were available ad libitum. The hair on the dorsum was clipped 24 hours before exposure. For induction, the animals received a total application of 50 µl undiluted dibutyl ether with each animal receiving two 25 µl amounts on separate sites. Five days later, each guinea pig received on virgin sites six challenge applications of 25 µl undiluted aliquots. A rechallenge was performed 9 days after the first challenge. Skin reaction was scored by the method of Draize at 24 and 48 hours after application. Under the conditions of the study, the animals did not respond with dermal hypersensitivity reactions when challenged with dibutyl ether. The mean scores 24 hours after day 5 and day 14 challenge were 0.8 and 0.0, respectively. No individual scores were greater than 1.0 (maximum possible score of 8). According to these results, dibutyl ether has no sensitization potency.
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