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EC number: 215-716-0 | CAS number: 1345-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-06-26 to 2013-07-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and OECD guideline compliant study on dibismuth trisulphide
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- , adopted September 7, 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Version / remarks:
- of 30 May 2008 (Official Journal L 142, 31/05/2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Version / remarks:
- , August 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other: "Traditional protocol" of the OECD guideline no. 403
- Limit test:
- yes
Test material
- Reference substance name:
- Dibismuth trisulphide
- EC Number:
- 215-716-0
- EC Name:
- Dibismuth trisulphide
- Cas Number:
- 1345-07-9
- Molecular formula:
- Bi2S3
- IUPAC Name:
- dibismuth trisulphide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Species and strain: Hsd.Brl.Han:Wist rat
- Source: Toxi-Coop Zrt. Cserkesz u. 90. H-1103 Budapest Hungary
- Age at study initiation: 10-11 weeks old
- Weight at study initiation: (P) Males: 333-347 g; Females: 218-248 g;
- Housing: Before mating: 2 or 3 animals of the same sex/ cage
- Diet: ssniff® SM R/M-Z+H "Autoclavable complete feed for rats and mice – breeding and maintenance" produced by ssniff Spezialdiäten GmbH, D-59494 Soest, Germany ad libitum, and tap water from municipal supply, as for human consumption, from 500 mL bottles ad libitum.
- Water: drinking water
- Acclimatization time: 20 days (9 day to the test apparatus)
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 3 °C
- Humidity: 30 - 70 %
- Air changes: 10-15 air exchanges/hour by central air-condition system.
- Photoperiod: 12 hours daily, from 6.00 a.m. to 6.00 p.m.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: anodised aluminium Flow Past Exposure Chamber
- Exposure chamber volume: 1.66 L (3x8 animal ports)
- Method of holding animals in test chamber: polycarbonate restraining tubes
- Source and rate of air: 1.03 L/min fresh test atmosphere to each of the 24 animal ports
TEST ATMOSPHERE
- Brief description of analytical method used: Aerosol Light Scattering Photometer
VEHICLE
- Concentration of test material in vehicle (if applicable): 5 mg/L
TEST ATMOSPHERE (if not tabulated)
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 2 to 4 µm - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Limit test: 5.20 mg/L
- No. of animals per sex per dose:
- 5 animals/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations: During the exposure and daily for 14 days; Weighing: exposure Day 0 (prior to exposure) and Days 1, 3, 7 and 14
- Necropsy of survivors performed: yes - Statistics:
- No statistical analysis was performed in the study
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No animal died during the study.
- Clinical signs:
- other: In four male and two female animals test item related clinical signs were found one hour after completion of the exposure and in one female animal on first day of observation period. The clinical signs represented the decreased and increased activity and
- Body weight:
- On basis of body weight and body weight gain data, there was no notable test item effect observable in the exposed animals.
- Gross pathology:
- The dark grey color of test item Dibismuth Trisulfide caused discolouration in the lungs tissues, other local alterations were not found in the respiratory tract.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- In the Acute Inhalation Toxicity Study according to OECD guideline 403 the acute inhalation median lethal concentration (4hr LC50) of test item dibismuth trisulfide in rats was considered to be greater than 5.20 mg/L.
- Executive summary:
Under the conditions of the present Acute Inhalation Toxicity Study according to OECD guideline 403, no deaths occurred in a group of ten rats exposed for four hours to a mean achieved atmospheric test item aerosol concentration of 5.20 mg/L. The acute inhalation median lethal concentration (4hr LC50) of test item dibismuth trisulfide, in Wistar Crl:(WI) BR rats, was therefore considered to be greater than 5.20 mg/L. Based on the result of this inhalation toxicity study, dibismuth trisulfide was not classified according to the Globally Harmonized Classification System (GHS) and Regulation (EC) No 12727/2008 (CLP).
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