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EC number: 403-500-0 | CAS number: 159120-95-3 CYRACURE (R) PHOTOINITIATOR UVI-6974; CYRACURE PHOTOINITIATOR UVI-6976
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Test Method, Annex Ⅴ (B.12) of Dir. 84/449/EEC
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- A mixture of: bis[4-diphenylsulfoniumphenyl]sulfide-bishexafluoroantimonate; thiophenoxyphenylsulfonium hexafluoroantimonate
- EC Number:
- 403-500-0
- EC Name:
- A mixture of: bis[4-diphenylsulfoniumphenyl]sulfide-bishexafluoroantimonate; thiophenoxyphenylsulfonium hexafluoroantimonate
- Cas Number:
- 159120-95-3
- Molecular formula:
- not applicable-multi-constituent substance
- IUPAC Name:
- (4-{[4-(diphenylsulfaniumyl)phenyl]sulfanyl}phenyl)diphenylsulfanium; diphenyl[4-(phenylsulfanyl)phenyl]sulfanium; tris(hexafluorostibanuide)
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- No. of animals per sex per dose:
- Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 24hours
Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 48hours
Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 72hours
Male: 1000mg/kg; No. of animals: 5; Sacrifice time: 24hours
Male: 1000mg/kg; No. of animals: 5; Sacrifice time: 48hours
Male: 1000mg/kg; No. of animals: 5; Sacrifice time: 72hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 24hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 48hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 72hours
Female: 1000 mg/kg; No. of animals: 6; Sacrifice times: 24hours
Female: 1000 mg/kg; No. of animals: 7; Sacrifice times: 48hours
Female: 1000mg/kg; No. of animals: 5; Sacrifice times: 72hours
Results and discussion
- Additional information on results:
- Doses producing toxicity:
In a preliminary experiment 100% of the animals died at 5000mg/kg, while 83% died at 2000mg/kg and 17% at 1500mg/kg.
At the 1000mg/kg dose level one animal (17%) showed pilo-erection and at 500mg/kg no effects were found. In the final experiment at 1000mg/kg no animals died.
Ratio polychromatic/normochromatic: a 1000mg/kg b.w.: not significantly different from the negative controls.
Observations:
The mean number of micronuclei per group and the mean ratio of polychromatic to normochromatic erythro's were calculated. The test groups
showed no increase in the frequency of micronuclei. In negative control animals, the incidence of micronuclei was found to be in the range of
historical data. In positive control animals, a decrease in the ratio polychr.lnorm. erythro's and a statistically significant increase in the number of
micronuclei.
It is concluded that this test is valid and that the substance can be considered as not mutagenic under the experimental conditions of the
micronucleus test.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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