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EC number: 212-091-6 | CAS number: 762-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to current guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- 10 male rats/dose and 10 female rat/dose received single oral applications o 250-5000mg/kg bw by gavage diluted in aqua destillata. The animals were observed for 14 days post application for mortality and clinical signs. Gross pathological examinations were performed on animals that died during the observation period.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl phosphonate
- EC Number:
- 212-091-6
- EC Name:
- Diethyl phosphonate
- Cas Number:
- 762-04-9
- Molecular formula:
- C4H11O3P
- IUPAC Name:
- diethyl phosphonate
- Test material form:
- other: colourless liquid
- Details on test material:
- content not given
the substance is described as technically pur
colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 160 - 200 g
- Fasting period before study: ca 16 hours
- Diet ad libitum:
- Water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
no details given
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqua destillata
- Details on oral exposure:
- male rats/dose and female rat/dose received single oral applications o 250-5000 mg/kg bw by gavage diluted in aqua destillata. the animals were observed for 14 days post application for mortality and clinical signs. Gross pathological examinations were performed on animals that died during the observation period.
- Doses:
- 250, 500, 1000, 2500, , 3000 (females only), 3500, 4000, 4500, 5000 mg/kg bw in aqua destillata
- No. of animals per sex per dose:
- 10 male rats/dose and 10 female rats per dose
20 females with 3500 mg/kg bw - Control animals:
- no
- Details on study design:
- 10 male rats/dose and 10 female rat/dose received single oral applications o 250-5000mg/kg bw by gavage diluted in aqua destillata. the animals were observed for 14 days post application for mortality and clinical signs. Gross pathological examinations were performed on animals that died during the observation period. LD 50 is callculated according to Lichtfield and Wilcoxon (1949) I. Phrarmacol Exp Therap 96, , 99
- Statistics:
- LD 50 is calculated according to Lichtfield and Wilcoxon (1949) I. Phrarmacol Exp Therap 96, , 99
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 340 mg/kg bw
- 95% CL:
- >= 3 985 - <= 4 726
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 500 mg/kg bw
- 95% CL:
- >= 3 238 - <= 3 784
- Mortality:
- males:
250, 500, 1000, 2500 mg/kg bw: no rat died
3500 mg/kg bw, 1/10; 4000 3/10 died within 1 day
4500 mg/kg bw: 5/10 and 5000 mg/kg bw; 9/10 did within 2 hrs and 2 days
females:
250, 500, 1000, 2500 mg/kg bw: no rat died
3000 mg/kg b:; 2/10within 1 day, 3500 mg/kg bw: 11/20 within 1-2 days
4000 mg/kg bw8/10 within 5 h - 1 day; 4500 mg/kg bw: 9/10 within 4hours to 1 day
5000 mg/kg bw : 10/10 within 4 hours to 1 day - Clinical signs:
- other: apathy, rough fur, prone position, sedation, reduceed motility, accelerated breathing surviving rats showed normal behavior
- Gross pathology:
- animals that died during the observation period showed distended lungs, pale liver, kidneys and spleens with partly spotted surface
- Other findings:
- no data
Applicant's summary and conclusion
- Executive summary:
10 male rats/dose and 10 female rat/dose received single oral applications o 250-5000 mg/kg bw by gavage diluted in aqua destillata. The animals were observed for 14 days post application for mortality and clinical signs. Gross pathological examinations were performed on animals that died during the observation period. Animals displayed apathy and accelerated breathing. Mortality occurred from 3000 mg/kg bw onwards. The LD50(male) is 4350 mg/kg bw and LD50(female) is 3500 mg/kg bw.
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