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Diss Factsheets
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EC number: 246-376-1 | CAS number: 24634-61-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Acceptable, reasonably well documented publication Deviations: - missing data: an evaluation of the rate and extent of absorption is not given, and an investigation of tissue distribution and metabolic pathway was not conducted. - less tha 95 % of the administered dose was recovered in excreta, and the post-exposure period consisted of only 4 days instead of 7.
- Justification for type of information:
- Since the sorbate anion in the (eco-) toxicologically relevant moiety and its presence in dissociated or non-dissociated form is entirely determined by pH, extrapolation to potassium sorbate or vice versa is not considered to be restricted in any way.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.36 (Toxicokinetics)
- Version / remarks:
- adopted 1988
- Deviations:
- yes
- Remarks:
- , please refer to "rationale for reliability incl. deficiencies" above
- Principles of method if other than guideline:
- Method followed: None specified at the time of conduct
Treated mice were maintained in metabolic cages, expired air was collected in two successive absorption vessels containing either sodium or potassium hydroxide solution, and isotope recovery in urine and faeces was measured. - GLP compliance:
- no
Test material
- Reference substance name:
- Hexa-2,4-dienoic acid
- EC Number:
- 203-768-7
- EC Name:
- Hexa-2,4-dienoic acid
- Cas Number:
- 110-44-1
- Molecular formula:
- C6H8O2
- IUPAC Name:
- hexa-2,4-dienoic acid
- Details on test material:
- - Name of test material: 1-14C radiolabelled sorbic acid
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: adult
- Weight at study initiation: about 22 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- - Volume administered: 0.5 ml
- Specific activity of test substance: 640 000 cpm. or 850 000 cpm.
VEHICLE
- Concentration in vehicle: 0.136 % or 15.5 %; 1280000 or 1700000 c.p.m./mL - Duration and frequency of treatment / exposure:
- single administration
Doses / concentrations
- Remarks:
- Doses / Concentrations:
40 or 3000 mg/kg b.w.
- No. of animals per sex per dose / concentration:
- Low dose: 4 females
High dose: 2 females - Control animals:
- no
- Details on study design:
- - Post dose observation period: 4 days
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: exhaled air, urine, faeces;
- Time and frequency of sampling: exhalation, faeces and urine were collected daily and radioactivity was measured.
- Isotope recovery
- Method type(s) for identification: Chromatography
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Within 4 days, approx 80 % of the administered radioactivity was expired as radioactive carbon dioxide, only 2.6-5.4 % via urine and less than 1 % via faeces. In urine, 0.7 % of the administered dose could be recovered as unchanged sorbic acid, and 0.2-0.6 % was recovered as muconic acid.
Tox. behaviour: none
Any other information on results incl. tables
Adverse effects on prolonged exposure: none
Applicant's summary and conclusion
- Conclusions:
- The major metabolic pathway was concluded to be oxidation to CO2 and water.
Decision on results of acute toxicity tests conducted in the framework of this study: substance is well tolerated.
The extrapolation from sorbic acid to potassium sorbate or vice versa is considered not to be restricted in any way, since the determinant of potential toxicity is on the "sorbate" anion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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