Registration Dossier
Registration Dossier
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EC number: 219-351-8 | CAS number: 2422-91-5
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: subacute study
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD TG 412
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Methylidynetri-p-phenylene triisocyanate
- EC Number:
- 219-351-8
- EC Name:
- Methylidynetri-p-phenylene triisocyanate
- Cas Number:
- 2422-91-5
- Molecular formula:
- C22H13N3O3
- IUPAC Name:
- 1-[bis(4-isocyanatophenyl)methyl]-4-isocyanatobenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure (if applicable):
- nose only
- Vehicle:
- other: dry conditioned air
- Details on mating procedure:
- not applicable because it is a subacute study
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- 6 hours per day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.47, 3.9, 34.9 mg/m³
Basis:
other: gravimetric concentrations
- No. of animals per sex per dose:
- 5
- Control animals:
- other: yes: dry conditioned air
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOEC
- Effect level:
- 34.9 mg/m³ air (analytical)
- Based on:
- act. ingr.
- Sex:
- male/female
- Basis for effect level:
- other: adverse effects on reproductive organs or tissues
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No adverse effects on reproductive organs or tissues were observed in a subacute inhalation study with rats at 34.9 mg/m³.
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