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Diss Factsheets
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EC number: 219-351-8 | CAS number: 2422-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: subacute study
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD TG 412
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure (if applicable):
- nose only
- Vehicle:
- other: dry conditioned air
- Details on mating procedure:
- not applicable because it is a subacute study
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- 6 hours per day
- Remarks:
- Doses / Concentrations:
0, 0.47, 3.9, 34.9 mg/m³
Basis:
other: gravimetric concentrations - No. of animals per sex per dose:
- 5
- Control animals:
- other: yes: dry conditioned air
- Dose descriptor:
- NOEC
- Effect level:
- 34.9 mg/m³ air (analytical)
- Based on:
- act. ingr.
- Sex:
- male/female
- Basis for effect level:
- other: adverse effects on reproductive organs or tissues
- Reproductive effects observed:
- not specified
- Conclusions:
- No adverse effects on reproductive organs or tissues were observed in a subacute inhalation study with rats at 34.9 mg/m³.
Reference
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 34.9 mg/m³
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Based on the subacute inhalation study, there is no indication of a reproductive toxicity potential.
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In a subacute inhalation toxicity study (OECD TG 412) male/female Wistar rats per dose group were nose-only exposed for 4 weeks (6 hours /day, 5 days/week) to the aerosolized substance. The mean actual concentrations (gravimetric) were 0.47, 3.9 and 34.9 mg Triphenylmethane-4,4',4''-triisocyanate/m³. No adverse effects on reproductive organs or tissues were observed at 34.9 mg/m³.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Neither a developmental study (OECD TG 414) nor a testing proposal for such a study are available. Data waiver is claimed.
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The toxicological database for inhaled Triphenylmethane-4,4',4''-triisocyanate demonstrates consistently that toxicity is associated only with the portal of entry (respiratory tract). Acute and subacute inhalation studies with Triphenylmethane-4,4',4''-triisocyanate show toxicity confined to the respiratory tract. In general, the toxicological effects observed resulting from inhalation exposure of Triphenylmethane-4,4',4''-triisocyanate, reveal a pattern characteristic for local irritation and its sequelae with lack of systemic toxicity. This mode of action is in line with other diisocyanates and wholly consistent with the chemical reactivity of the isocyanate functional group. Developmental toxicity studies with other diisocyanates (MDI, TDI and HDI) have shown no evidence of any diisocyanate being a developmental toxicant. Mild effects on the foetuses seen with high level exposures to these diisocyanates are considered secondary to the toxicity to the respiratory system of the exposed dams. Therefore, it is proposed that, based on the similar major mode of action as port of entry toxicant, the lack of developmental toxicity seen with MDI, TDI and HDI applies equally to Triphenylmethane-4,4',4''-triisocyanate (many-to-one read-across). Therefore, based on read across there is no indication of a developmental toxicity potential. Protection against respiratory tract toxicity will protect against any secondary effects. In addition, the need to adopt risk management measures to protect against the sensitising potential of these chemicals provides enhanced safeguards. Taking all these points into account (weight of evidence), it is concluded that developmental toxicity is not an endpoint of concern for Triphenylmethane-4,4',4''-triisocyanate.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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