Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 226-002-3 | CAS number: 5205-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Range-finding study, test procedure in accordance with national standard methods with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Guideline:
- other: according to Federal Hazardous Substances Act (FHSA) procedure
- Principles of method if other than guideline:
- In the FHSA test six eyes are exposed, but not rinsed. A fixed dose of 0.1 ml of Dimethylaminopropyl methacrylamide is used. This is placed inside the lower eyelid, which forms a culdesac. Ocular reactions are read either with the unaided eye or a magnifier at 24, 48 and 72 h after exposure. In
the FHSA test, no readings after 72 h are specified. Use of fluorescein after 24-h reading is optional in the FHSA version, but is not mentioned in
the Draize procedure. Readings are recorded as separate scores for lesions of the cornea, iris, and conjunctiva. Serious lesions such as pannus,
phlyctena, or ulceration of the cornea are considered to be off-scale responses that are to be noted separately. - GLP compliance:
- not specified
Test material
- Reference substance name:
- N-[3-(dimethylamino)propyl]methacrylamide
- EC Number:
- 226-002-3
- EC Name:
- N-[3-(dimethylamino)propyl]methacrylamide
- Cas Number:
- 5205-93-6
- Molecular formula:
- C9H18N2O
- IUPAC Name:
- N-[3-(dimethylamino)propyl]-2-methylacrylamide
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Dimethylaminopropyl Methacrylamide
- Molecular weight (if other than submission substance): 170.25 g/mol
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: no data
- Weight at study initiation: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated eyes of the test animals serve as the control
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 72 hour(s)
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no removal of the test substance
SCORING SYSTEM: Draize J.H. et al. (1944) (original values)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Primary irritation index
- Basis:
- mean
- Remarks:
- according to Scoring system of Draize et al. 1944
- Time point:
- 24/48/72 h
- Score:
- 66.3
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- other: A corrosive-like action to the eye lids of 4 rabbits was determined. The iris could not be viewed because of corneal opacity in 3 of 4 rabbits.
- Remarks:
- Reversibility scores were not measured after 7 and 21 days.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 60
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 80
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 80
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 80
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 5
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- iris score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 16
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 16
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 16
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 16
- Reversibility:
- not specified
- Remarks on result:
- other: mean of the three time points
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
- Irreversible damage to cornea, iris, conjunctiva 21 days after exposure in at least one animal
- Mean Draize score in 2 of 3 animals:
- Reversible adverse effects on cornea, iris, conjunctiva
- Mean Draize score in 2 of 3 animals:
- Reversible in 21 days
- Reversible in 7 days
Classification of eye irritation studies according GHS-criteria/original values
Substance: 3-Dimethylaminopropyl methacrylamide DMAPMA CAS: 5205-93-6
Internal No.: LITSU 96-0160
Date/Expert: 06-12-18/Am
Evaluation at the end of the table
Animal No. |
Corneal opacity/Hornhauttrübung[Scores] orignal values |
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
60 |
60 |
60 |
|
|
|
|
2 |
80 |
80 |
80 |
|
|
||
3 |
80 |
80 |
80 |
|
|
|
|
4 |
80 |
80 |
80 |
|
|
|
|
|
|
|
|
|
|
|
|
Animal No. |
Iritis/Regenbogenhautentzündung[Scores] original values |
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
5 |
5 |
5 |
|
|
|
|
2 |
0 |
0 |
0 |
|
|
||
3 |
0 |
0 |
0 |
|
|
|
|
4 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
|
|
Animal No. |
Conjunctiva /Bindehautrötung/ödem[Scores] original values |
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
16 |
16 |
16 |
|
|
||
2 |
16 |
16 |
16 |
|
|
|
|
3 |
16 |
16 |
16 |
|
|
|
|
4 |
16 |
16 |
16 |
|
|
|
There
was a discernible opacity or ulceration of the cornea during the
readings made at 24, 48 or 72 hours. There
was an obvious swelling of the conjunctivae, excluding cornea and iris,
with partial eversion of the lids.There
was destruction or irreversible change at any tissue in 24 hours or less.
The iris could not be viewed because of corneal opacity in 3 of 4 rabbits.
A corrosive-like action to the eye lids of 4 rabbits. Corneal opacity in 3 of 4 rabbits!
Classification GHS: Hazard Category |
1 irreversible effects |
Classification Criteria for serious Eye Damage/Eye Irritation
Category 1
corneal opacity≥ 3
iritis ≥ 1,5
Category 2
corneal opacity≥1
iritis≥1
redness≥2
chemosis≥2
Subcategory 2A
Subcategory 2B
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Dimethylaminopropyl methacrylamide has a corrosive-like action to the eye lids of 4 rabbits. Effects on the iris could not be evaluates in 3 of 4 rabbits due to severe corneal opacity.
Classification: risk of serious damage to eyes, GHS-category: 1, H318, causes serious eye damage - Executive summary:
In a primary eye irritation study, 0.1 mL of Dimethylaminopropyl methacrylamide (purity: >= 98%) was instilled into the conjunctival sac of 4 rabbits (strain, sex, source, age, weight: no data) for 72 hours. The eyes were not washed. Irritation was scored by the method of Draize et al. (1944).
In this study, Dimethylaminopropyl methacrylamide was a strong eye irritant. It was found to have a corrosive-like action to the eye lids of the rabbits and induced changes of the eye which were considered irreversible.
Based in EU and OECD criteria the DMAPMA is considered a category 1 eye irritant with the potential to cause irreversible damage to the eye.
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.