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Diss Factsheets
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EC number: 202-852-0 | CAS number: 100-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Older Russian industrial hygiene and toxicology studies do not use international guideline methods, and insufficient data is presented on methods to determine whether they are valid.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- On the Toxicology of 2-Vinyl Pyridine
- Author:
- Dukhovnaya AI
- Year:
- 1 966
- Bibliographic source:
- Gigiena truda (Occupational Hygiene) 3:9-13
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Accepted chronic inhalation experimental protocol used in Russian scientific institutes, consisting of a 1 week adjustment period with no exposure, 10 weeks of exposure at 4 hours per day, then a 4 week recovery period.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-vinylpyridine
- EC Number:
- 202-879-8
- EC Name:
- 2-vinylpyridine
- Cas Number:
- 100-69-6
- IUPAC Name:
- 2-vinylpyridine
- Test material form:
- other: liquid
- Details on test material:
- Described as a dark brown oily liquid with a pungent and irritating odor. The molecular weight was 105, specific gravity of 0.97 at 20 degrees C, boiling point of 158 degrees C, at 760 mm Hg.
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Details on inhalation exposure:
- 2VP vapours in a poisoning chamber.
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 4 hours per day
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.005 mg/L
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
0.001 mg/L
Basis:
analytical conc.
- No. of animals per sex per dose:
- 12
- Control animals:
- yes
Results and discussion
Results of examinations
- Body weight and weight changes:
- effects observed, treatment-related
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 0.001 mg/L air (analytical)
- Basis for effect level:
- other: No change in weight gain or clinical chemistry/haematology
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Changes in arterial blood pressure was a major endpoint in this study. The low dose group (0.001 mg/L) displayed a decrease in blood pressure, whereas the high dose group (0.005 mg/L) showed a decrease but with high variability in blood pressure. Nerve /muscle excitability was also measured (no information on methods). There was no difference in nerve/muscle excitability in the low dose group, but there was a decrease in this parameter in the high dose group, where a decrease in nerve/muscle excitability was seen in weeks 4 - 8, then an apparent recovery toward control levels in weeks 9 -13 (which included a cessation of exposure). In the high dose group, there were transient changes in leucocyte and lymphocyte counts, but these returned to control levels during the recovery period. No changes in clinical chemistry values were noted in either dose group. Postmortem examination of the internal organs showed nonspecific changes in the high dose group only. These were described as focal bronchopneumonia, blood vessel dysfunctions and lymphohystiocytic reactive states of parenchymous organs. Focal bronchopneumonia was also found among control animals.
.Applicant's summary and conclusion
- Conclusions:
- 2-Vinylpyridine was studied in a 10-week inhalation study with a 4 week recovery period, in rats, via an inhalation chamber, at doses of 0, 0.001 mg/L and 0.005 mg/L. The details of this study are not provided; however, other data from this publication are in general agreement with values established using standard guideline methods. Hence, this study has some basis of validity. The NOAEC for rats under these conditions of exposure is 0.001 mg/L.
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