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EC number: 814-217-0 | CAS number: 353258-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. EPA Fate, Transport, and Transformation Guidelines. OPPTS 835.1230 Adsorption/Desorption (October 2008)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- batch equilibrium method
- Media:
- soil
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: 14C-IN-QEK31
Lot #: 1572460
Radiochemical purity: 97.8%
Specific activity: 69.12 μCi/mg - Radiolabelling:
- yes
Study design
- Test temperature:
- 20 ± 2°C
Batch equilibrium or other method
- Analytical monitoring:
- yes
Matrix propertiesopen allclose all
- Matrix no.:
- #1
- Matrix type:
- sandy loam
- % Clay:
- 11
- % Silt:
- 30
- % Sand:
- 59
- % Org. carbon:
- 1.3
- pH:
- 7.7
- CEC:
- 8.8 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.07
- Matrix no.:
- #2
- Matrix type:
- silty clay loam
- % Clay:
- 35
- % Silt:
- 52
- % Sand:
- 13
- % Org. carbon:
- 2
- pH:
- 6.2
- CEC:
- 17.5 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.03
- Matrix no.:
- #3
- Matrix type:
- clay
- % Clay:
- 49
- % Silt:
- 37
- % Sand:
- 14
- % Org. carbon:
- 2
- pH:
- 7.7
- CEC:
- 16.3 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.03
- Matrix no.:
- #4
- Matrix type:
- sandy loam
- % Clay:
- 11
- % Silt:
- 36
- % Sand:
- 53
- % Org. carbon:
- 0.56
- pH:
- 6.5
- CEC:
- 14.8 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.07
- Matrix no.:
- #5
- Matrix type:
- loamy sand
- % Clay:
- 7
- % Silt:
- 15
- % Sand:
- 78
- % Org. carbon:
- 1.7
- pH:
- 5.6
- CEC:
- 8.5 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.18
- Matrix no.:
- #6
- Matrix type:
- sandy loam
- % Clay:
- 7
- % Silt:
- 30
- % Sand:
- 63
- % Org. carbon:
- 2.6
- pH:
- 5.9
- CEC:
- 8.1 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.04
Duration of adsorption equilibration
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- Nominal application rates: 0.01, 0.05, 0.1, 0.5, 1 μg a.i./mL for all the six soils
Duration of desorption equilibrationopen allclose all
- Sample no.:
- #1
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- Amount of Test Material Present in the Adsorbed State (µg): 4.34 & 4.47 for replicate 1 & 2 respectively
- Sample no.:
- #2
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- Amount of Test Material Present in the Adsorbed State (µg): 12.17 & 12.10 for replicate 1 & 2 respectively
- Sample no.:
- #3
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- Amount of Test Material Present in the Adsorbed State (µg): 7.71 & 7.61 for replicate 1 & 2 respectively
- Sample no.:
- #4
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- Amount of Test Material Present in the Adsorbed State (µg): 4.42 & 4.44 for replicate 1 & 2 respectively
- Sample no.:
- #5
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- Amount of Test Material Present in the Adsorbed State (µg): 8.15 & 8.28 for replicate 1 & 2 respectively
- Sample no.:
- #6
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- Amount of Test Material Present in the Adsorbed State (µg): 7.95 & 7.99 for replicate 1 & 2 respectively
Results and discussion
Adsorption coefficientopen allclose all
- Sample No.:
- #1
- Type:
- Kd
- Value:
- 0.75 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Nambsheim soil
- Sample No.:
- #2
- Type:
- Kd
- Value:
- 4.16 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Tama soil
- Sample No.:
- #3
- Type:
- Kd
- Value:
- 1.61 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Lleida soil
- Sample No.:
- #4
- Type:
- Kd
- Value:
- 0.81 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Porterville soil
- Sample No.:
- #5
- Type:
- Kd
- Value:
- 1.74 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Speyer soil
- Sample No.:
- #6
- Type:
- Kd
- Value:
- 1.65 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Sassafras soil
- Sample No.:
- #1
- Type:
- other: Kom
- Value:
- 34 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Nambsheim soil
- Sample No.:
- #2
- Type:
- other: Kom
- Value:
- 122 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Tama soil
- Sample No.:
- #3
- Type:
- other: Kom
- Value:
- 46 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Lleida soil
- Sample No.:
- #4
- Type:
- other: Kom
- Value:
- 82.9 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Porterville soil
- Sample No.:
- #5
- Type:
- other: Kom
- Value:
- 57.9 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Speyer soil
- Sample No.:
- #6
- Type:
- other: Kom
- Value:
- 54.8 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Sassafras soil
- Sample No.:
- #1
- Type:
- Koc
- Value:
- 57.5 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Nambsheim soil
- Sample No.:
- #2
- Type:
- Koc
- Value:
- 208 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Tama soil
- Sample No.:
- #3
- Type:
- Koc
- Value:
- 80.6 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Lleida soil
- Sample No.:
- #4
- Type:
- Koc
- Value:
- 144 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Porterville soil
- Sample No.:
- #5
- Type:
- Koc
- Value:
- 102 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Speyer soil
- Sample No.:
- #6
- Type:
- Koc
- Value:
- 96.8 other: mL/g
- Temp.:
- 20 °C
- Matrix:
- Sassafras soil
Partition coefficientsopen allclose all
- Sample No.:
- #1
- Type:
- other: Kd
- Matrix:
- Nambsheim soil
- Remarks on result:
- other: 0.76 & 1 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #2
- Type:
- other: Kd
- Matrix:
- Tama soil
- Remarks on result:
- other: 3.66 & 4.29 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #3
- Type:
- other: Kd
- Matrix:
- Lleida soil
- Remarks on result:
- other: 1.61 & 2.04 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #4
- Type:
- other: Kd
- Matrix:
- Porterville soil
- Remarks on result:
- other: 0.78 & 0.97 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #5
- Type:
- other: Kd
- Matrix:
- Speyer soil
- Remarks on result:
- other: 1.65 & 2.03 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #6
- Type:
- other: Kd
- Matrix:
- Sassafras soil
- Remarks on result:
- other: 1.57 & 2 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #1
- Type:
- other: Kdom
- Matrix:
- Nambsheim soil
- Remarks on result:
- other: 34.6 & 45.2 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #2
- Type:
- other: Kdom
- Matrix:
- Tama soil
- Remarks on result:
- other: 108 & 126 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #3
- Type:
- other: Kdom
- Matrix:
- Lleida soil
- Remarks on result:
- other: 45.9 & 58.3 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #4
- Type:
- other: Kdom
- Matrix:
- Porterville soil
- Remarks on result:
- other: 80.5 & 99.9 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #5
- Type:
- other: Kdom
- Matrix:
- Speyer soil
- Remarks on result:
- other: 55 & 67.7 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #6
- Type:
- other: Kdom
- Matrix:
- Sassafras soil
- Remarks on result:
- other: 35.7 & 45.5 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #1
- Type:
- other: Kdoc
- Matrix:
- Nambsheim soil
- Remarks on result:
- other: 58.5 & 76.5 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #2
- Type:
- other: Kdoc
- Matrix:
- Tama soil
- Remarks on result:
- other: 183 & 215 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #3
- Type:
- other: Kdoc
- Matrix:
- Lleida soil
- Remarks on result:
- other: 80.3 & 102 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #4
- Type:
- other: Kdoc
- Matrix:
- Porterville soil
- Remarks on result:
- other: 140 & 173 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #5
- Type:
- other: Kdoc
- Matrix:
- Speyer soil
- Remarks on result:
- other: 97.1 & 120 mL/g for replicate 1 and 2 respectively
- Sample No.:
- #6
- Type:
- other: Kdoc
- Matrix:
- Sassafras soil
- Remarks on result:
- other: 60.4 & 77 mL/g for replicate 1 and 2 respectively
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- The Kd values were 0.75, 4.16, 1.61, 0.81, 1.74, and 1.65 mL/g for the Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively.
The Kom values were 34.0, 122, 46.0, 82.9, 57.9, and 54.8 mL/g for the Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively.
The Koc values were 57.5, 208, 80.6, 144, 102, and 96.8 mL/g for the Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively.
The mean desorption Kd, values ranged from 0.76 mL/g in the Nambsheim soil to 4.29 mL/g in the Tama soil. The mean desorption Kd,om values ranged from 34.6 mL/g in the Nambsheim soil to 126 mL/g in the Tama soil. The mean desorption Kd,oc values ranged from 58.5 mL/g in the Nambsheim soil to 215 mL/g in the Tama soil.
Mass balance (%) at end of desorption phaseopen allclose all
- Sample no.:
- #1
- Duration:
- 24 h
- % Desorption:
- 99.7
- Sample no.:
- #2
- Duration:
- 24 h
- % Desorption:
- 98.5
- Sample no.:
- #3
- Duration:
- 24 h
- % Desorption:
- 96.7
- Sample no.:
- #4
- Duration:
- 24 h
- % Desorption:
- 99.8
- Sample no.:
- #5
- Duration:
- 24 h
- % Desorption:
- 96.5
- Sample no.:
- #6
- Duration:
- 24 h
- % Desorption:
- 100.9
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The analysis of adsorption supernatants conducted for the highest test concentration for each soil demonstrated that 14C-IN-QEK31 accounted between 98.24% and 100.00% of radioactivity in all test soils indicating the stability of test item during the 24-h experimental conditions.
The average material balance was quantitative and ranged from 96.5 to 100.9% of the applied radioactivity in all soils. - Executive summary:
The adsorption and desorption properties of 14C-IN-QEK31 to six different soils were investigated in the laboratory. The calculated adsorption (Kd, Kom and Koc) and desorption coefficients (Kd1, Kd2, Kd1,om, Kd1,oc, Kd2,om and Kd2,oc) and the Freundlich adsorption isotherm parameters (KF, KFom, KFoc, 1/n and R2) are reported.
The texture of the soils included three sandy loams (Nambsheim, Porterville and Sassafras), a silty clay loam (Tama), a loamy sand (Speyer) and a clay (Lleida). The per cent organic matter (Walkley-Black method) of the soils ranged from 0.97 to 4.4% and the pH in aqueous 0.01 M CaCl2 ranged from 5.3 to 7.5. The study was conducted as per procedures outlined in OECD Guideline 106 (January 2000) and U. S. EPA test guidelines OPPTS 835.1230 (October 2008). The adsorption experiment was performed using the batch equilibration method on soils with five nominal test concentrations (0.01, 0.05, 0.1, 0.5 and 1 µg/mL) of the test item prepared in aqueous 0.01 M CaCl2. The highest concentration chosen was commensurate with the likely concentration in soil at the projected application rates of 1.0 kg/ha. Two desorption cycles were performed on samples treated at the highest test concentration. A 1:2 (w/v) soil-to-solution ratio was used in the preliminary and definitive experiments. The sorption coefficients, Kd, Kom and Koc were calculated for each soil at each test concentration.
The Kd values were 0.75, 4.16, 1.61, 0.81, 1.74, and 1.65 mL/g for the Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively.
The Kom values were 34.0, 122, 46.0, 82.9, 57.9, and 54.8 mL/g for the Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively.
The Koc values were 57.5, 208, 80.6, 144, 102, and 96.8 mL/g for the Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively.
The values for the Freundlich adsorption isotherm parameters, KF, KFom, KFoc, 1/n and R2 were derived from the linear form of the Freundlich equation for all test soils. A plot of Kd and Koc against soil pH showed no correlation of pH with adsorption parameters. The value of the Freundlich adsorption isotherm parameter, KF, was 0.53, 2.68, 1.16, 0.55, 1.31 and 1.27 for the Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively. The organic matter and organic carbon normalized Freundlich adsorption isotherm coefficients KFom and KFoc, respectively, were calculated for all the soils. The KFom values were 24.1, 78.8, 33.1, 56.7, 43.7 and 28.9 while the KFoc values were 40.8, 134, 58.0, 98.2, 77.1 and 48.8 for Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively. The values for the Freundlich constant, 1/n, were 0.8630, 0.8693, 0.8831, 0.8550, 0.8992 and 0.9070 for Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively. The correlation coefficient (R2) for the analyses were 0.9996, 0.9997, 0.9998, 0.9995, 0.9991 and 0.9996 for Nambsheim, Tama, Lleida, Porterville, Speyer and Sassafras soils, respectively, for the adsorption phase, indicating the Freundlich equation adequately predicts the adsorption of the test item over the concentration range studied.
The desorption coefficients, Kd1, Kd2, Kd1,om, Kd1,oc, Kd2,om and Kd2,oc were calculated for each soil at the highest test concentration. The mean desorption Kd, values ranged from 0.76 mL/g in the Nambsheim soil to 4.29 mL/g in the Tama soil. The mean desorption Kd,om values ranged from 34.6 mL/g in the Nambsheim soil to 126 mL/g in the Tama soil. The mean desorption Kd,oc values ranged from 58.5 mL/g in the Nambsheim soil to 215 mL/g in the Tama soil.
The per cent 14C-IN-QEK31 desorbed from the soils during two desorption intervals (D1 and D2) was calculated and totaled (DT) for each soil at the highest test concentration. The total per cent desorbed (DT) values ranged from 35.2% in the Tama soil to 64.5% in the Porterville soil. In general, lower desorption values were observed in second desorption. The highest desorption was observed in Nambsheim and Porterville soils in first and second desorption, respectively. The lowest desorption was observed in Tama soil in both first and second desorption intervals.
The analysis of adsorption supernatants conducted for the highest test concentration for each soil demonstrated that 14C-IN-QEK31 accounted between 98.24% and 100.00% of radioactivity in all test soils indicating the stability of test item during the 24-h experimental conditions.
The average material balance was quantitative and ranged from 96.5 to 100.9% of the applied radioactivity in all soils.
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