Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 603-923-2 | CAS number: 135590-91-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in soil
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in soil
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 Jun 1992 - 12 Dec 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-3 (Photodegradation Studies on Soil)
- GLP compliance:
- yes
- Radiolabelling:
- yes
- Analytical monitoring:
- yes
- Analytical method:
- high-performance liquid chromatography
- other: Radioactivity was determined by LSC
- Light source:
- other: polychromatic light
- Light spectrum: wavelength in nm:
- 290 - 800
- Details on light source:
- - Other: The spectrum of sunlight was simulated by an ORIGINAL HANAU SUNTEST
photoreactor (Hanau Quarzlampen GmbH, Hanau, Germany)
The light intensity was determined by a chemical actinometer (uranylsulfate/oxalate) to the 1.37fold value compared to that of 52° North at June and sea level. - Details on test conditions:
- TEST SYSTEM
- Application procedure:
- Volume of test solution used/treatment: applied onto twelve 16 cm2 steel plates (17.1 µg active ingredient per plate)
- Method of application: soil samples treated with 17.1 g U-14C-dichlorophenyl-labelled AE F107892 per 16 cm2 at 25°C and approx. 40% mwrc for a total of 17 days taking into account day/night intervals of 12 hours each
- Details of traps for volatile, if any: Mineralisation and formation of volatile components were determined by suitably equipped traps.
MEASUREMENTS:
After 0, 1, 3, 8, 15 and 17 days, duplicate soil samples were extracted and analysed for test substance and transformation products by high performance liquid chromatography (HPLC) with radioanalytical detection techniques. Non-extractable residues were determined by combustion/LSC. In parallel, dark controls were investigated for comparison of profiles with those of irradiated samples. - Duration:
- 17 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 17.1 other: µg U-14C-dichlorophenyl-labelled AE F107892
- DT50:
- 5.6 d
- Transformation products:
- yes
Reference
Findings:
Recoveries ranged from approx. 84% to 103% of total applied radioactivity with an exception for one irradiation series at the two late sampling intervals (day 15: 74.0 %, day 17: 69.2 %).Further investigations for samples at day 17 by acidification and additional extraction of soil did not result in an increase in the material balance.
The extractable portion of radioactivity declined from 102.0% (irradiation series I) and 100.3% (series II) of applied dose by day 0 to values of 61.6% and 41.1%, respectively, by the end of the study, day 17. The non-extractable residues increased from 0.5% (series I) / 0.4% (series II) by day 0 to 19.0% / 18.9% by day 17. The formation of14C-carbon dioxide accounted for 3.9% of applied radioactivity at the end of the irradiation period. Other volatile material amounted to 5.2% of applied dose at the same time.
Metabolic profile:
The parent compound AE F107892 showed a decline from 96.4% (series I) / 95.3% (series II) of applied dose by day zero to 5.9% / 2.8% by day 17, respectively. The monoester compound mefenpyr-ethyl AE F113225 was observed as a major metabolite at peak values of 27.6% / 27.5% (series I / series II) by day 3. The pyrazole carboxylic acid AE F094270 was found as a minor component at maximum levels of 6.6% of applied radiolabel in the course of the study.
An unknown metabolite (reporting title “M8“) was detected at a peak value of 11.0 % of applied radiolabel (average, day 1) and subjected to extensive structure elucidation by gas chromatography (GC) and mass spectrometry (MS) with and without derivatisation and H-NMR. The efforts resulted in structural proposals proposing that the skeleton of the parent compound was still intact with an additional oxygen atom attached or inserted to it. Further unknown components were detected at <3.5 % of applied radiolabel.
The disappearance of AE F107892 was described by a simple first order kinetic approach. The disappearance time for 50 % (DT50) was calculated to 5.6 days under approximation for outdoor conditions.
Description of key information
Phototransformation on soil is not a significant process for the elimination of the substance in the outdoor soil environment.
Key value for chemical safety assessment
- Half-life in soil:
- 5.6 d
Additional information
A soil photolysis study was conducted according to EPA Guideline Subdivision N 161-3 (1995). Soil samples of 16 cm² each treated with 17.1 μg U-14C-dichlorophenyl-labelled parent substance were irridated at 25°C and approx. 40% mwrc for a total of 17 days taking into account day/night intervals of 12 hours each. The amount of test item applied referred to a maximum application rate of 90 g/ha in the field. The soil samples were extracted and analysed for test substance and transformation products by high performance liquid chromatography (HPLC) with radioanalytical detection techniques. Non-extractable residues were determined by combustion/LSC. In parallel, dark controls were investigated for comparison of profiles with those of irradiated samples.
The disappearance of the substance was described by a simple first order kinetic approach. The disappearance time for 50% (DT50) was calculated to 5.6 days under approximation for outdoor conditions.
Photolysis on soil surfaces is of limited contribution to the elimination of the parent compound from the outdoor environment. Phototransformation products observed undergo rapid further degradation as indicated by the significant formation of volatile radioactivity (14CO2). The phototransformation products formed can be assumed to be stabilized by the conditions of the experiment, for example, by sterilisation of soil from intensive irradiation and the use of acidic soil. Phototransformation products contain sub-structures similar to the parent compound (e. g. ester). This implies rapid conversion by other abiotic (i.e. hydrolysis) and microbially induced processes for a field situation. Considering the rapid biotically-induced hydrolysis of the parent compound this precursor is reduced significantly before phototransformation products as observed in the test may be formed under outdoor conditions. A significant extent or, accumulation of phototransformation products of the substance in a natural soil environment is thus highly unlikely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.