Registration Dossier
Registration Dossier
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EC number: 442-070-9 | CAS number: 329039-38-5
Endpoint summary
Administrative data
Description of key information
oral, rat LD50 > 2000 mg/kg bw
dermal, rat LD50 > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Oral exposure:
After single oral application of 2000 mg/kg bw of the test item, no deaths occurred during the GLP-Guideline study. No mortality and no clinical signs of toxicity were observed up to the end of the 14-day observation period in all animals. The median lethal dose of methyldiacetoxyisopropoxy silane after a single oral administration to rats of both sexes, observed over a period of 14 days is greater than 2000 mg/kg body weight.
Dermal exposure:
After dermal application of 2000 mg/kg bw of the test item for 24 hours, no deaths occurred during the GLP-Guideline study. No mortality and no clinical signs of toxicity were observed up to the end of the 14-day observation period in all animals. The median lethal dose of methyldiacetoxyisopropoxy silane after a single dermal administration to rats of both sexes, observed over a period of 14 days is greater than 2000 mg/kg body weight.
Justification for classification or non-classification
According to DSD (67/548/EEC) and CLP (1272/2008/EC) methyldiacetoxyisopropoxy silane does not meet the criteria to be classified regarding this endpoint.
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